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• W2895164039 endingPage "2246" @default.
• W2895164039 startingPage "2235" @default.
• W2895164039 abstract "Synthetic musk compounds are extensively used in personal care and cosmetic products around the world. Because they are not completely removed in sewage treatment plants, they eventually end up in aquatic environments. The aim of this review was to summarize published information on effects of polycyclic musks on aquatic organisms and to discuss whether the experimental design of toxicological studies involving these substances could influence the results obtained. With the exception of one study run in a flow-through system, all published toxicological studies on synthetic polycyclic musks have been conducted in semi-static or even static systems. Based upon data in the literature and our own results, we conclude that in toxicological tests with semi-static set-ups, concentrations of polycyclic musks decrease with time between bath exchanges, and, as a result, tested organisms are not being exposed to stable concentrations but rather to concentration pulses. The duration and character of these pulses are influenced mainly by aeration of experimental baths, as polycyclic musks have a tendency to volatilize from water baths. Under semi-static conditions, tested organisms may be subjected to lower concentration of the tested substance for relatively long periods. Those levels may even fall below the limits of quantification. During these periods, some level of detoxification and/or elimination (depuration) of the toxicant may reduce toxic effect of the previous exposures. Consequently, toxicity of polycyclic musk substances for aquatic organisms obtained under these conditions may be underestimated. Based upon existing data in the literature, therefore, it is very difficult to correctly estimate risk of polycyclic musks to aquatic organisms." @default.
• W2895164039 created "2018-10-12" @default.
• W2895164039 creator A5000077758 @default.
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• W2895164039 creator A5044227579 @default.
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• W2895164039 creator A5070348265 @default.
• W2895164039 date "2019-02-01" @default.
• W2895164039 modified "2023-10-18" @default.
• W2895164039 title "Effect of polycyclic musk compounds on aquatic organisms: A critical literature review supplemented by own data" @default.
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• W2895164039 doi "https://doi.org/10.1016/j.scitotenv.2018.10.028" @default.
• W2895164039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326456" @default.
• W2895164039 hasPublicationYear "2019" @default.

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