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- W2895192239 abstract "Pesticides are a mixture of chemical substances used to kill pests. Apart from their toxicity to pests, thy affect nontarget organisms. They also generate free radicals producing reactive oxygen species (ROS) which can disturb cellular pathways by inhibiting various enzymes or receptors. Pesticides also induce oxidative DNA damage, DNA adducts, and single or double strand DNA breaks. Various mechanisms of DNA repair deal with such damages and help to maintain cell integrity. Alteration in DNA repair genes modulates the individual's susceptibility towards DNA repair and various diseases. Biological monitoring provides a useful tool for the estimation of genetic risk in populations exposed to pesticides. Large numbers of evidences show that occupational exposure to pesticides in agricultural workers has been associated with an increased incidence of various diseases such as cancer, Parkinson's disease, Alzheimer's disease, reproductive disorders, and birth defects. In this review, we have discussed occupational pesticide exposure, various mechanisms of DNA damage caused by pesticides, DNA repair mechanisms, biomonitoring tools, and various diseases caused by pesticide exposure." @default.
- W2895192239 created "2018-10-12" @default.
- W2895192239 creator A5045458260 @default.
- W2895192239 creator A5078302234 @default.
- W2895192239 date "2018-01-01" @default.
- W2895192239 modified "2023-10-10" @default.
- W2895192239 title "Occupational pesticide exposure, impaired DNA repair, and diseases" @default.
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- W2895192239 doi "https://doi.org/10.4103/ijoem.ijoem_45_18" @default.
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