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- W2895194025 abstract "Introduction: Post-operative sleep and circadian rhythm disturbances were associated with prolonged post-operative convalescence, respiratory and cardiovascular morbidity. Sleep disturbances have been shown to be due to decreased levels of circulating melatonin after surgery. If this sleep pattern and circadian rhythm is recycled, outcome after surgery could be improved. Therefore, aim of this study was to observe the effect of melatonin on quality of sleep in patients undergoing laparoscopic cholecystectomy (LC). Methods: Hundred patients of LC participated in this randomized, placebo-controlled, double-blind, clinical trial. Patients were randomized equally into Group A who received 6 mg melatonin tablets 45 minutes before sleep for three days after surgery and Group B who received placebo. Results: Melatonin usage results in decrease in sleep latency (SL) as compared to placebo (13.6 ± 14.95 vs 20.10 ± 16.18 minutes, p 0.04). There was also increased total sleep duration (TSD) on postoperative day (POD) 1 (p 0.004) and POD 2 (p 0.001) in group A. There was decrease in day time naps and night awakenings after surgery in group A though it was not significant statistically. Subjective assessment of sleep on visual analogue scale (VAS) showed reduced sleep score (p 0.001) and decreased pain (p 0.02) in group A on POD 1. Statistically significant difference was not observed in fatigue or general well being among groups. Conclusion: Results of this study could demonstrate that melatonin as a single agent could improve quality of sleep by decreasing sleep latency and increasing total sleep duration." @default.
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- W2895194025 date "2018-09-01" @default.
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- W2895194025 title "Efficacy of melatonin on sleep quality after laparoscopic cholecystectomy" @default.
- W2895194025 doi "https://doi.org/10.1016/j.hpb.2018.06.189" @default.
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