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- W2895256786 abstract "We theoretically investigate the mechanical stability of three-dimensional (3D) foam geometry in a cell sheet and apply its understandings to epithelial integrity and cell delamination. Analytical calculations revealed that the monolayer integrity of cell sheet is lost to delamination by a spontaneous symmetry breaking, inherently depending on the 3D foam geometry of cells; i.e., the instability spontaneously appears when the cell density in the sheet plane increases and/or when the number of neighboring cells decreases, as observed in vivo. The instability is also facilitated by the delaminated cell-specific force generation upon lateral surfaces, which are driven by cell-intrinsic genetic programs during cell invasion and apoptosis in physiology. In principle, this instability emerges from the force balance on the lateral boundaries among cells. Additionally, taking into account the cell-intrinsic force generation on apical and basal sides, which are also broadly observed in morphogenesis, homeostasis, and carcinogenesis, we found apically/basally directed cell delaminations and pseudostratified structures, which could universally explain mechanical regulations of epithelial geometries in both physiology and pathophysiology." @default.
- W2895256786 created "2018-10-12" @default.
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- W2895256786 date "2018-10-03" @default.
- W2895256786 modified "2023-09-27" @default.
- W2895256786 title "Mechanical Instability Leading Epithelial Cell Delamination" @default.
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