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• W2895294863 abstract "Di(2-ethylhexyl) phthalate (DEHP) is an omnipresent environmental pollutant with endocrine disrupting properties. As a plasticizer, DEHP can be leach from the plastic to transfer the external environment and thus enters the animal food chain, causing serious damage to the animal organs. The heat-shock response (HSR) comprising heat-shock protein (HSPs) and heat-shock transcription factor (HSFs) plays a pivotal role in various toxic stress conditions. For the sake of investigating the effects of DEHP exposure on cardiac toxicity and the regulation of HSR, male quail were fed the diet with 0, 250, 500 and 750 mg/kg DEHP by gavage administration for 45 days. Histopathological changes including cardiomyocyte swelling and muscle fiber dilatation were observed in the hearts exposed to DEHP. During the DEHP treatment, the mRNA expression of HSP60 and HSP70 were universally reduced, while the expression of other HSPs (HSP10, HSP25, HSP27, HSP40, HSP47, HSP90, HSP110) had different degrees of growth. In addition, the levels of HSF1, HSF2, and HSF3 were significantly increased. Given the facts above, DEHP exposure induced the toxic effects of quail heart. DEHP exposure did great harm to HSR via affecting the synthesis of HSFs to mediate the transcription of the HSPs. Ultimately, this study provided new evidence that DEHP-induced cardiotoxicity in quail was related to activation of HSR and playing a protective role." @default.
• W2895294863 created "2018-10-12" @default.
• W2895294863 creator A5001996792 @default.
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• W2895294863 creator A5086155499 @default.
• W2895294863 creator A5090366405 @default.
• W2895294863 date "2019-01-01" @default.
• W2895294863 modified "2023-10-18" @default.
• W2895294863 title "Modulation of heat-shock response is associated with Di (2-ethylhexyl) phthalate (DEHP)-induced cardiotoxicity in quail (Coturnix japonica)" @default.
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• W2895294863 doi "https://doi.org/10.1016/j.chemosphere.2018.10.002" @default.
• W2895294863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30300839" @default.
• W2895294863 hasPublicationYear "2019" @default.
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