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- W2895316996 abstract "Aims: To report overall and progression-free survival among patients who underwent synchronous resection of primary colorectal cancer and liver metastases with or without preoperative treatment. Methods: We performed a retrospective analysis of patients who underwent liver resection for synchronous colorectal metastases. We analyzed patient characteristics and baseline investigations following tumour board review. Recurrence and mortality were examined using Kaplan-Meier survival curves. Results: Between 2010 and 2017, 111 patients underwent liver resection for colorectal adenocarcinoma of which 33 patients had synchronous resection of primary and metastatic liver tumour. 10 patients underwent preoperative treatment and 23 patients had upfront surgery. Median age was 58.1 vs 65.8 years respectively (p=0.0086). 3-year and 5-year overall survival for all patients were 64.7% and 30.8%, respectively, with no difference between both groups (HR 1.971, 95%CI: 0.466-8.332, log rank test p=0.3). Patients with preoperative treatment had poorer progression-free survival (log rank test p=0.0527). Median progression-free survival was 12.2 months in pretreatment group vs 19.0 months for patients with upfront surgery. Patients with upfront surgery had fewer instances of extrahepatic recurrence compared to those with pretreatment (27.3% vs 87.5%, p=0.0198). More patients with pretreatment had rectal cancer (70.0% vs 4.35%, p=0.0002). The overall and progression-free survival for patients with rectal and colon cancer was similar.Tabled 1EP01A-010 Table 1[Outcomes in terms of Survival]Overall survivalAllPretreatmentNo pretreatmentP-value1-year overall survival25 (96.3%)7 (87.5%)18 (100.0%)0.3083-year overall survival11 (64.7%)4 (66.7%)7 (63.6%)1.0005-year overall survival4 (30.8%)1 (20.0%)3 (37.5%)1.000Progression-free survivalAllPretreatmentNo pretreatmentP-value1-year progression-free survival16 (59.3%)5 (71.4%)11 (55.0%)0.6633-year progression-free survival5 (21.7%)0 (0.0%)5 (27.8%)0.5455-year progression-free survival2 (10.0%)0 (0.0%)2 (13.3%)1.000 Open table in a new tab Conclusion: Selection of patients for preoperative treatment did not result in statistically significant difference in mortality compared to upfront surgery. Patients who had upfront synchronous resection of colorectal primary and liver metastases had statistically non-significant lower recurrence rates." @default.
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- W2895316996 date "2018-09-01" @default.
- W2895316996 modified "2023-10-06" @default.
- W2895316996 title "To determine if there is a difference in outcomes for patients undergoing synchronous primary colorectal cancer and liver resection with or without preoperative treatment" @default.
- W2895316996 doi "https://doi.org/10.1016/j.hpb.2018.06.2541" @default.
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