FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895331301> ?p ?o ?g. }

• W2895331301 endingPage "833" @default.
• W2895331301 startingPage "826" @default.
• W2895331301 abstract "Glutamate is the most abundant excitatory neurotransmitter in the human brain, but in vivo imaging of acute fluctuations in glutamatergic levels has not been well established. The purpose of this study was to examine acute changes in glutamate after stimulation with N-acetylcysteine (NAC) using a simultaneous positron emission tomography/magnetic resonance spectroscopy (PET/MRS) approach. Ten healthy adult males were examined in two scanning sessions, and 5g NAC was administered 1 h prior to one of the scan sessions. Simultaneous PET/MR data were acquired using an integrated 3T PET/MR scanner. Glutamate (Glu), glutamine (Gln), and glutamate + glutamine (Glx) levels were assessed from MRS data collected from the basal ganglia with PRESS and from the left prefrontal cortex with PRESS and MEGAPRESS, and mGluR5 binding (BPND) was assessed from PET data collected with [18F]PSS232. NAC administration was associated with a significant reduction in Glx and Gln in the basal ganglia spectra, and in Glx in the frontal MEGAPRESS spectra (p < 0.05); no differences in [18F]PSS232 BPND were observed with NAC, although a correlation between pre-/post-treatment Glx and baseline BPnd was found. The MRS-visible Glx signal is sensitive to acute fluctuations in glutamate. The change in Glx was mostly driven by a change in Gln, lending weight to the notion that Gln can provide a proxy marker for neurotransmitter/synaptic glutamate. [18F]PSS232 binding is not sensitive to acute glutamate shifts independently, but was associated with the extent of glutamate liberation upon NAC stimulation." @default.
• W2895331301 created "2018-10-12" @default.
• W2895331301 creator A5002029958 @default.
• W2895331301 creator A5036774533 @default.
• W2895331301 creator A5038819354 @default.
• W2895331301 creator A5047331691 @default.
• W2895331301 creator A5080852796 @default.
• W2895331301 creator A5087643852 @default.
• W2895331301 creator A5088142967 @default.
• W2895331301 date "2019-01-01" @default.
• W2895331301 modified "2023-09-26" @default.
• W2895331301 title "Imaging glutamate redistribution after acute N-acetylcysteine administration: A simultaneous PET/MR study" @default.
• W2895331301 cites W1484925058 @default.
• W2895331301 cites W1523695827 @default.
• W2895331301 cites W1592375995 @default.
• W2895331301 cites W1966761076 @default.
• W2895331301 cites W1992379299 @default.
• W2895331301 cites W2001646924 @default.
• W2895331301 cites W2005904867 @default.
• W2895331301 cites W2016560067 @default.
• W2895331301 cites W2028643731 @default.
• W2895331301 cites W2038979894 @default.
• W2895331301 cites W2042539749 @default.
• W2895331301 cites W2043074519 @default.
• W2895331301 cites W2045185962 @default.
• W2895331301 cites W2062340864 @default.
• W2895331301 cites W2070149789 @default.
• W2895331301 cites W2070535876 @default.
• W2895331301 cites W2072209865 @default.
• W2895331301 cites W2074854542 @default.
• W2895331301 cites W2082454730 @default.
• W2895331301 cites W2085364760 @default.
• W2895331301 cites W2088045668 @default.
• W2895331301 cites W2096665338 @default.
• W2895331301 cites W2120453252 @default.
• W2895331301 cites W2120641057 @default.
• W2895331301 cites W2123739790 @default.
• W2895331301 cites W2124107177 @default.
• W2895331301 cites W2127421809 @default.
• W2895331301 cites W2146729652 @default.
• W2895331301 cites W2165124532 @default.
• W2895331301 cites W2165379966 @default.
• W2895331301 cites W2185428045 @default.
• W2895331301 cites W2195556413 @default.
• W2895331301 cites W2215573212 @default.
• W2895331301 cites W2219087973 @default.
• W2895331301 cites W2233987507 @default.
• W2895331301 cites W2292245145 @default.
• W2895331301 cites W2293968029 @default.
• W2895331301 cites W2607180956 @default.
• W2895331301 cites W2626743400 @default.
• W2895331301 cites W2756028355 @default.
• W2895331301 cites W2759955182 @default.
• W2895331301 cites W2760325968 @default.
• W2895331301 cites W2765996079 @default.
• W2895331301 cites W2770849010 @default.
• W2895331301 cites W78243157 @default.
• W2895331301 doi "https://doi.org/10.1016/j.neuroimage.2018.10.017" @default.
• W2895331301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296554" @default.
• W2895331301 hasPublicationYear "2019" @default.
• W2895331301 type Work @default.
• W2895331301 sameAs 2895331301 @default.
• W2895331301 citedByCount "16" @default.
• W2895331301 countsByYear W28953313012019 @default.
• W2895331301 countsByYear W28953313012020 @default.
• W2895331301 countsByYear W28953313012021 @default.
• W2895331301 countsByYear W28953313012022 @default.
• W2895331301 countsByYear W28953313012023 @default.
• W2895331301 crossrefType "journal-article" @default.
• W2895331301 hasAuthorship W2895331301A5002029958 @default.
• W2895331301 hasAuthorship W2895331301A5036774533 @default.
• W2895331301 hasAuthorship W2895331301A5038819354 @default.
• W2895331301 hasAuthorship W2895331301A5047331691 @default.
• W2895331301 hasAuthorship W2895331301A5080852796 @default.
• W2895331301 hasAuthorship W2895331301A5087643852 @default.
• W2895331301 hasAuthorship W2895331301A5088142967 @default.
• W2895331301 hasConcept C126322002 @default.
• W2895331301 hasConcept C134018914 @default.
• W2895331301 hasConcept C15744967 @default.
• W2895331301 hasConcept C169760540 @default.
• W2895331301 hasConcept C170493617 @default.
• W2895331301 hasConcept C185592680 @default.
• W2895331301 hasConcept C24998067 @default.
• W2895331301 hasConcept C2779349466 @default.
• W2895331301 hasConcept C2780648746 @default.
• W2895331301 hasConcept C515207424 @default.
• W2895331301 hasConcept C55493867 @default.
• W2895331301 hasConcept C61174792 @default.
• W2895331301 hasConcept C71924100 @default.
• W2895331301 hasConceptScore W2895331301C126322002 @default.
• W2895331301 hasConceptScore W2895331301C134018914 @default.
• W2895331301 hasConceptScore W2895331301C15744967 @default.
• W2895331301 hasConceptScore W2895331301C169760540 @default.
• W2895331301 hasConceptScore W2895331301C170493617 @default.
• W2895331301 hasConceptScore W2895331301C185592680 @default.
• W2895331301 hasConceptScore W2895331301C24998067 @default.
• W2895331301 hasConceptScore W2895331301C2779349466 @default.
• W2895331301 hasConceptScore W2895331301C2780648746 @default.

• next