Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895333491> ?p ?o ?g. }
- W2895333491 endingPage "6469" @default.
- W2895333491 startingPage "6455" @default.
- W2895333491 abstract "This work demonstrates how quantitative image analysis can assist in the characterization of continuous crystallization processes and in the proper selection of mathematical models for the early assessment of crystal quality. An active pharmaceutical ingredient presenting an elongated crystal habit was crystallized using two stirred tank crystallizers in series. With image analysis of the crystallization magma, the sources of crystal breakage in the crystallization cascade were identified, and the impact on crystal habit was evaluated quantitatively. As it is expected for particles presenting high aspect ratios, crystal breakage preferentially occurs in the smallest plane, perpendicular to the largest dimension. This phenomenon is hardly avoidable in downstream production, but it can be accounted for with a design approach based on the real crystal dimensions. The kinetic rate equations for nucleation and crystal growth were determined based on crystal width, from which a model for the accurate prediction..." @default.
- W2895333491 created "2018-10-12" @default.
- W2895333491 creator A5002133387 @default.
- W2895333491 creator A5022185737 @default.
- W2895333491 creator A5024278509 @default.
- W2895333491 creator A5063064473 @default.
- W2895333491 creator A5069491848 @default.
- W2895333491 creator A5076769095 @default.
- W2895333491 date "2018-10-05" @default.
- W2895333491 modified "2023-09-24" @default.
- W2895333491 title "Characterization of a Multistage Continuous MSMPR Crystallization Process Assisted by Image Analysis of Elongated Crystals" @default.
- W2895333491 cites W105695126 @default.
- W2895333491 cites W1960527654 @default.
- W2895333491 cites W1966919054 @default.
- W2895333491 cites W1972157024 @default.
- W2895333491 cites W1987837211 @default.
- W2895333491 cites W1992075296 @default.
- W2895333491 cites W1996768222 @default.
- W2895333491 cites W2001512736 @default.
- W2895333491 cites W2023564040 @default.
- W2895333491 cites W2023654300 @default.
- W2895333491 cites W2036601277 @default.
- W2895333491 cites W2045133945 @default.
- W2895333491 cites W2047707452 @default.
- W2895333491 cites W2050101634 @default.
- W2895333491 cites W2050269368 @default.
- W2895333491 cites W2058138179 @default.
- W2895333491 cites W2065550282 @default.
- W2895333491 cites W2070499430 @default.
- W2895333491 cites W2073010988 @default.
- W2895333491 cites W2075594220 @default.
- W2895333491 cites W2081244403 @default.
- W2895333491 cites W2087413605 @default.
- W2895333491 cites W2090854767 @default.
- W2895333491 cites W2091669252 @default.
- W2895333491 cites W2092996449 @default.
- W2895333491 cites W2095633770 @default.
- W2895333491 cites W2143367399 @default.
- W2895333491 cites W2168614130 @default.
- W2895333491 cites W2215963070 @default.
- W2895333491 cites W2286617896 @default.
- W2895333491 cites W2315703870 @default.
- W2895333491 cites W2317500619 @default.
- W2895333491 cites W2322156480 @default.
- W2895333491 cites W2325274076 @default.
- W2895333491 cites W2327651865 @default.
- W2895333491 cites W2396515136 @default.
- W2895333491 cites W2509885115 @default.
- W2895333491 cites W2522300283 @default.
- W2895333491 cites W2572757289 @default.
- W2895333491 cites W2573988657 @default.
- W2895333491 cites W2578311836 @default.
- W2895333491 cites W2595744132 @default.
- W2895333491 cites W4252929690 @default.
- W2895333491 doi "https://doi.org/10.1021/acs.cgd.8b00446" @default.
- W2895333491 hasPublicationYear "2018" @default.
- W2895333491 type Work @default.
- W2895333491 sameAs 2895333491 @default.
- W2895333491 citedByCount "15" @default.
- W2895333491 countsByYear W28953334912019 @default.
- W2895333491 countsByYear W28953334912020 @default.
- W2895333491 countsByYear W28953334912021 @default.
- W2895333491 countsByYear W28953334912022 @default.
- W2895333491 crossrefType "journal-article" @default.
- W2895333491 hasAuthorship W2895333491A5002133387 @default.
- W2895333491 hasAuthorship W2895333491A5022185737 @default.
- W2895333491 hasAuthorship W2895333491A5024278509 @default.
- W2895333491 hasAuthorship W2895333491A5063064473 @default.
- W2895333491 hasAuthorship W2895333491A5069491848 @default.
- W2895333491 hasAuthorship W2895333491A5076769095 @default.
- W2895333491 hasBestOaLocation W28953334912 @default.
- W2895333491 hasConcept C121332964 @default.
- W2895333491 hasConcept C159985019 @default.
- W2895333491 hasConcept C171250308 @default.
- W2895333491 hasConcept C185592680 @default.
- W2895333491 hasConcept C192562407 @default.
- W2895333491 hasConcept C199360897 @default.
- W2895333491 hasConcept C203036418 @default.
- W2895333491 hasConcept C26456737 @default.
- W2895333491 hasConcept C2779015675 @default.
- W2895333491 hasConcept C2780841128 @default.
- W2895333491 hasConcept C2781285689 @default.
- W2895333491 hasConcept C41008148 @default.
- W2895333491 hasConcept C61048295 @default.
- W2895333491 hasConcept C79191725 @default.
- W2895333491 hasConcept C8010536 @default.
- W2895333491 hasConcept C97355855 @default.
- W2895333491 hasConceptScore W2895333491C121332964 @default.
- W2895333491 hasConceptScore W2895333491C159985019 @default.
- W2895333491 hasConceptScore W2895333491C171250308 @default.
- W2895333491 hasConceptScore W2895333491C185592680 @default.
- W2895333491 hasConceptScore W2895333491C192562407 @default.
- W2895333491 hasConceptScore W2895333491C199360897 @default.
- W2895333491 hasConceptScore W2895333491C203036418 @default.
- W2895333491 hasConceptScore W2895333491C26456737 @default.
- W2895333491 hasConceptScore W2895333491C2779015675 @default.
- W2895333491 hasConceptScore W2895333491C2780841128 @default.
- W2895333491 hasConceptScore W2895333491C2781285689 @default.