Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895384398> ?p ?o ?g. }
- W2895384398 endingPage "1256" @default.
- W2895384398 startingPage "1248" @default.
- W2895384398 abstract "Dengue virus is a major pathogen, and severe infections can lead to life-threatening dengue hemorrhagic fever. Dengue virus exists as four serotypes, and dengue hemorrhagic fever is often associated with secondary heterologous infections. Antibody-dependent enhancement (ADE) may drive higher viral loads in these secondary infections and is purported to result from antibodies that recognize dengue virus but fail to fully neutralize it. Here we characterize two antibodies, 2C8 and 3H5, that bind to the envelope protein. Antibody 3H5 is highly unusual as it not only is potently neutralizing but also promotes little if any ADE, whereas antibody 2C8 has strong capacity to promote ADE. We show that 3H5 shows resilient binding in endosomal pH conditions and neutralizes at low occupancy. Immunocomplexes of 3H5 and dengue virus do not efficiently interact with Fcγ receptors, which we propose is due to the binding mode of 3H5 and constitutes the primary mechanism of how ADE is avoided. Immunity to one serotype of dengue virus can worsen disease following exposure to another serotype, a process called ‘antibody-dependent enhancement’. Grimes and colleagues characterize the function and structural basis of an unusual, potent and broadly neutralizing antibody that lacks such activity." @default.
- W2895384398 created "2018-10-12" @default.
- W2895384398 creator A5012247460 @default.
- W2895384398 creator A5012275154 @default.
- W2895384398 creator A5017598518 @default.
- W2895384398 creator A5022061077 @default.
- W2895384398 creator A5022666879 @default.
- W2895384398 creator A5023871527 @default.
- W2895384398 creator A5024393155 @default.
- W2895384398 creator A5027519967 @default.
- W2895384398 creator A5059959150 @default.
- W2895384398 creator A5064264305 @default.
- W2895384398 creator A5071377696 @default.
- W2895384398 creator A5072476030 @default.
- W2895384398 creator A5073612502 @default.
- W2895384398 creator A5074800971 @default.
- W2895384398 creator A5075242803 @default.
- W2895384398 creator A5088147193 @default.
- W2895384398 date "2018-10-15" @default.
- W2895384398 modified "2023-10-09" @default.
- W2895384398 title "Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus" @default.
- W2895384398 cites W1017348960 @default.
- W2895384398 cites W1513149807 @default.
- W2895384398 cites W1539796472 @default.
- W2895384398 cites W1785111426 @default.
- W2895384398 cites W1799716582 @default.
- W2895384398 cites W1911304984 @default.
- W2895384398 cites W1911753321 @default.
- W2895384398 cites W1985799231 @default.
- W2895384398 cites W1998511630 @default.
- W2895384398 cites W2000001441 @default.
- W2895384398 cites W2001568055 @default.
- W2895384398 cites W2002545308 @default.
- W2895384398 cites W2006158980 @default.
- W2895384398 cites W2008169728 @default.
- W2895384398 cites W2016266684 @default.
- W2895384398 cites W2017081541 @default.
- W2895384398 cites W2017577931 @default.
- W2895384398 cites W2028155324 @default.
- W2895384398 cites W2031578199 @default.
- W2895384398 cites W2032146255 @default.
- W2895384398 cites W2033540007 @default.
- W2895384398 cites W2036154503 @default.
- W2895384398 cites W2045725941 @default.
- W2895384398 cites W2051298245 @default.
- W2895384398 cites W2052669763 @default.
- W2895384398 cites W2053490656 @default.
- W2895384398 cites W2056713455 @default.
- W2895384398 cites W2061766263 @default.
- W2895384398 cites W2066235960 @default.
- W2895384398 cites W2067389058 @default.
- W2895384398 cites W2069745616 @default.
- W2895384398 cites W2073949924 @default.
- W2895384398 cites W2084766126 @default.
- W2895384398 cites W2100891069 @default.
- W2895384398 cites W2109993434 @default.
- W2895384398 cites W2114296756 @default.
- W2895384398 cites W2120772351 @default.
- W2895384398 cites W2122364694 @default.
- W2895384398 cites W2124547357 @default.
- W2895384398 cites W2127324477 @default.
- W2895384398 cites W2131222241 @default.
- W2895384398 cites W2131849805 @default.
- W2895384398 cites W2133764756 @default.
- W2895384398 cites W2142758749 @default.
- W2895384398 cites W2144081223 @default.
- W2895384398 cites W2151240643 @default.
- W2895384398 cites W2155705845 @default.
- W2895384398 cites W2156864709 @default.
- W2895384398 cites W2159407190 @default.
- W2895384398 cites W2163341755 @default.
- W2895384398 cites W2164382089 @default.
- W2895384398 cites W2168044318 @default.
- W2895384398 cites W2169886236 @default.
- W2895384398 cites W2181263624 @default.
- W2895384398 cites W2206904506 @default.
- W2895384398 cites W2460107925 @default.
- W2895384398 cites W2470330280 @default.
- W2895384398 cites W2493146871 @default.
- W2895384398 cites W2610442760 @default.
- W2895384398 cites W2760337654 @default.
- W2895384398 cites W2772146448 @default.
- W2895384398 cites W2788855073 @default.
- W2895384398 doi "https://doi.org/10.1038/s41590-018-0227-7" @default.
- W2895384398 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7051845" @default.
- W2895384398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323338" @default.
- W2895384398 hasPublicationYear "2018" @default.
- W2895384398 type Work @default.
- W2895384398 sameAs 2895384398 @default.
- W2895384398 citedByCount "28" @default.
- W2895384398 countsByYear W28953843982018 @default.
- W2895384398 countsByYear W28953843982019 @default.
- W2895384398 countsByYear W28953843982020 @default.
- W2895384398 countsByYear W28953843982021 @default.
- W2895384398 countsByYear W28953843982022 @default.
- W2895384398 countsByYear W28953843982023 @default.
- W2895384398 crossrefType "journal-article" @default.
- W2895384398 hasAuthorship W2895384398A5012247460 @default.