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- W2895404681 abstract "Background: Patients with hepatocellular carcinoma (HCC) not suitable for standard loco-regional treatments who are on the waiting for liver transplantation (LT) are at high risk of drop-out. Conformal radiotherapy (CRT) may represent a potential alternative for such patients but its oncological outcome in that setting was never assessed. We aimed to assess the oncological results of this strategy. Methods: Patients undergoing LT for HCC with or without prior CRT between 2005 and 2017 were compared using 1:3 propensity score matching (PSM) for postoperative and oncological outcomes. Results: During the study period, LT for HCC with or without CRT was performed in 24 and 259 patients, respectively. After PSM, 23 patients with CRT were compared to 66 control subjects. There was no difference between the CRT and non-CRT groups in terms of severe morbidity (34.8% vs. 24.2%, p = 0.327), arterial complications (34.8% vs. 19.7%, p = 0.142) and biliary complications (26.1% vs. 18.2%, p = 0.547). Complete pathological response was observed in 17.4% and 25.8% of patients in the CRT and non-CRT groups, respectively. The 1-, 3-, and 5-year overall survivals were 81.8%, 81.8% and 72.7% in the CRT group and 89.0%, 76.2% and 66.2% in the non-CRT group (p = 0.860). The corresponding 1-, 3- and 5-year disease-free survivals were 77.3%, 77.3% and 68.7% vs. 85.4%, 68.0% and 61.7% (p = 0.829). Conclusion: Patients with HCC treated with CRT prior to LT achieved equivalent oncological results compared to those having no CRT. CRT represents a satisfactory alternative neoadjuvant therapy for patients with HCC not suitable for standard loco-regional therapies." @default.
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- W2895404681 date "2018-09-01" @default.
- W2895404681 modified "2023-09-27" @default.
- W2895404681 title "Neoadjuvant conformal radiotherapy as a bridge to liver transplantation for hepatocellular carcinoma" @default.
- W2895404681 doi "https://doi.org/10.1016/j.hpb.2018.06.2384" @default.
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