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- W2895420439 abstract "ABSTRACT To construct a prototrophic Corynebacterium glutamicum strain that efficiently produces pyruvate from glucose, the effects of inactivating RamA, a global regulator responsible for activating the oxidative tricarboxylic acid (TCA) cycle, on glucose metabolism were investigated. ΔramA showed an increased specific glucose consumption rate, decreased growth, comparable pyruvate production, higher formation of lactate and acetate, and lower accumulation of succinate and 2-oxoglutarate compared to the wild type. A significant decrease in pyruvate dehydrogenase complex activity was observed for ΔramA, indicating reduced carbon flow to the TCA cycle in ΔramA. To create an efficient pyruvate producer, the ramA gene was deleted in a strain lacking the genes involved in all known lactate- and acetate-producing pathways. The resulting mutant produced 161 mM pyruvate from 222 mM glucose, which was significantly higher than that of the parent (89.3 mM; 1.80-fold)." @default.
- W2895420439 created "2018-10-12" @default.
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- W2895420439 date "2019-02-01" @default.
- W2895420439 modified "2023-09-26" @default.
- W2895420439 title "Engineering of <i>Corynebacterium glutamicum</i> as a prototrophic pyruvate-producing strain: Characterization of a <i>ramA</i>-deficient mutant and its application for metabolic engineering" @default.
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- W2895420439 doi "https://doi.org/10.1080/09168451.2018.1527211" @default.
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