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- W2895431111 abstract "Background: Cognitive deficits have been described in individuals with heart failure (HF), with worsening at the time of acute decompensation and volume overload. We evaluated transcranial doppler cerebral blood flow velocities (CBFVs), as an index of cerebral perfusion, before and after IV diuresis, in an outpatient HF clinic, to explore mechanisms of cognitive dysfunction during HF decompensation, and to test if velocities improved after diuresis. Methods: In an ongoing study of cognitive evaluation in an outpatient HF diuresis clinic, patients had CBFVs measured before diuresis, and again after completion of daily dosing of IV diuresis (1-7 days later, whenever they were considered to be euvolemic and no longer needing diuresis). Clinical signs and symptoms of volume overload including pulmonary edema, peripheral edema, and ascites were tracked by clinic staff. CBFVs (cm/sec) in several intracranial vessels were compared within individuals, with paired t-tests, before and after completion of the IV diuresis treatment. In linear regression models, we evaluated improvement in volume status in association with change in CBFVs. Results: A total of 21 individuals completed CBFVs before and after diuresis. In all vessels tested (table), CBFVs decreased after diuresis, and in many cases, went from a high to a normal value. Although numbers were small, those individuals with the most improvement in their volume status had more improvement in CBFVs in several but not all vessels. For several vessels, improvement in CBFV was significantly associated with improvement on some cognitive tests. Conclusions: CBFVs are frequently elevated in individuals with decompensated heart failure, with return to a normal range after diuresis. Further evaluation of CBFV as a potential mediator of cognitive dysfunction in HF is warranted." @default.
- W2895431111 created "2018-10-12" @default.
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- W2895431111 date "2018-01-22" @default.
- W2895431111 modified "2023-09-27" @default.
- W2895431111 title "Abstract TP192: Change in Cerebral Blood Flow Velocities Before and After Diuresis in an Outpatient Heart Failure Clinic" @default.
- W2895431111 doi "https://doi.org/10.1161/str.49.suppl_1.tp192" @default.
- W2895431111 hasPublicationYear "2018" @default.
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