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- W2895435742 abstract "In this issue of Blood , Morschhauser et al report the safety and efficacy of lenalidomide in combination with obinutuzumab and establish the recommended phase 2 dose (RP2D). 1 Rituximab in combination with lenalidomide (R 2 ) has favorable efficacy and toxicity in relapsed and untreated follicular lymphoma (FL) and is now entering the treatment landscape of FL. 2-4 Obinutuzumab, a glycoengineered type II anti-CD20 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC), may be an attractive partner to lenalidomide that can exert immunomodulatory effects via natural killer (NK) and T cells for the treatment of relapsed or refractory (R/R) FL. The question is whether the potentially enhanced ADCC activity of obinutuzumab will translate into enhanced synergism with lenalidomide and result in an improved next-generation R 2 ." @default.
- W2895435742 created "2018-10-12" @default.
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- W2895435742 date "2018-10-04" @default.
- W2895435742 modified "2023-09-27" @default.
- W2895435742 title "Next-generation therapy for follicular lymphoma" @default.
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- W2895435742 doi "https://doi.org/10.1182/blood-2018-08-868117" @default.
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