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- W2895470003 abstract "Precise control of the glutathione/glutathione disulfide (GSH/GSSG) redox balance is vital for the developing embryo, but regulatory mechanisms are poorly understood. We developed a novel, mechanistic mass-balance model for GSH metabolism in the organogenesis stage (gestational day 10.0-11.13) rat conceptus predicting the dynamics of 8 unique metabolites in 3 conceptal compartments: the visceral yolk sac (VYS), the extra-embryonic fluid (EEF) and the embryo proper (EMB). Our results show that thiol concentrations in all compartments are well predicted by the model. Protein synthesis is predicted to be a major efflux pathway for all amino acid precursors of GSH synthesis and an essential model element. Our model provides quantitative insights in the transport fluxes and enzymatic fluxes needed to maintain thiol redox balances under normal physiological conditions. This is crucial to further elucidate the mechanisms through which chemical exposure can perturb redox homeostasis, causing oxidative stress, and potentially birth defects." @default.
- W2895470003 created "2018-10-12" @default.
- W2895470003 creator A5023884929 @default.
- W2895470003 creator A5053232867 @default.
- W2895470003 creator A5079954964 @default.
- W2895470003 creator A5080561091 @default.
- W2895470003 date "2018-12-01" @default.
- W2895470003 modified "2023-10-16" @default.
- W2895470003 title "A mechanistic model for thiol redox dynamics in the organogenesis stage rat conceptus" @default.
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- W2895470003 doi "https://doi.org/10.1016/j.reprotox.2018.09.005" @default.
- W2895470003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30292673" @default.
- W2895470003 hasPublicationYear "2018" @default.
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