FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895474133> ?p ?o ?g. }

• W2895474133 abstract "The presence of a reservoir of latently infected cells in HIV-infected patients is a major barrier towards finding a cure. One active cure strategy is to find latency-reversing agents that induce viral reactivation, thus leading to immune cell recognition and elimination of latently infected cells, known as the shock-and-kill strategy. Therefore, the identification of molecules that reactivate latent HIV and increase immune activation has the potential to further these strategies into the clinic. Here, we characterized synthetic molecules composed of a TLR2 and a TLR7 agonist (dual TLR2/7 agonists) as latency-reversing agents and compared their activity with that of the TLR2 agonist Pam2CSK4 and the TLR7 agonist GS-9620. We found that these dual TLR2/7 agonists reactivate latency by 2 complementary mechanisms. The TLR2 component reactivates HIV by inducing NF-κB activation in memory CD4+ T cells, while the TLR7 component induces the secretion of TNF-α by monocytes and plasmacytoid dendritic cells, promoting viral reactivation in CD4+ T cells. Furthermore, the TLR2 component induces the secretion of IL-22, which promotes an antiviral state and blocks HIV infection in CD4+ T cells. Our study provides insight into the use of these agonists as a multipronged approach targeting eradication of latent HIV." @default.
• W2895474133 created "2018-10-12" @default.
• W2895474133 creator A5033598125 @default.
• W2895474133 creator A5034983452 @default.
• W2895474133 creator A5036762753 @default.
• W2895474133 creator A5039731384 @default.
• W2895474133 creator A5042773644 @default.
• W2895474133 creator A5057585798 @default.
• W2895474133 creator A5066015523 @default.
• W2895474133 creator A5074840577 @default.
• W2895474133 creator A5075506645 @default.
• W2895474133 creator A5085311927 @default.
• W2895474133 creator A5085715902 @default.
• W2895474133 date "2018-10-04" @default.
• W2895474133 modified "2023-09-26" @default.
• W2895474133 title "Dual TLR2 and TLR7 agonists as HIV latency-reversing agents" @default.
• W2895474133 cites W1485326960 @default.
• W2895474133 cites W1497870368 @default.
• W2895474133 cites W1498574963 @default.
• W2895474133 cites W1617495083 @default.
• W2895474133 cites W1655860314 @default.
• W2895474133 cites W1659719610 @default.
• W2895474133 cites W1690275817 @default.
• W2895474133 cites W1772394217 @default.
• W2895474133 cites W1793506120 @default.
• W2895474133 cites W1823200218 @default.
• W2895474133 cites W1929740795 @default.
• W2895474133 cites W1964076408 @default.
• W2895474133 cites W1965971815 @default.
• W2895474133 cites W1974488636 @default.
• W2895474133 cites W1980474989 @default.
• W2895474133 cites W1980668957 @default.
• W2895474133 cites W1986500032 @default.
• W2895474133 cites W1995744610 @default.
• W2895474133 cites W2002258333 @default.
• W2895474133 cites W2007136776 @default.
• W2895474133 cites W2011626958 @default.
• W2895474133 cites W2012640887 @default.
• W2895474133 cites W2013158821 @default.
• W2895474133 cites W2014818809 @default.
• W2895474133 cites W2023565096 @default.
• W2895474133 cites W2024502371 @default.
• W2895474133 cites W2027798298 @default.
• W2895474133 cites W2029679352 @default.
• W2895474133 cites W2030844138 @default.
• W2895474133 cites W2031579881 @default.
• W2895474133 cites W2035947707 @default.
• W2895474133 cites W2045452873 @default.
• W2895474133 cites W2052756867 @default.
• W2895474133 cites W2055218233 @default.
• W2895474133 cites W2060737851 @default.
• W2895474133 cites W2061480204 @default.
• W2895474133 cites W2063628696 @default.
• W2895474133 cites W2066053575 @default.
• W2895474133 cites W2068504903 @default.
• W2895474133 cites W2070051114 @default.
• W2895474133 cites W2082170266 @default.
• W2895474133 cites W2088493593 @default.
• W2895474133 cites W2089575955 @default.
• W2895474133 cites W2090646713 @default.
• W2895474133 cites W2101516953 @default.
• W2895474133 cites W2106051882 @default.
• W2895474133 cites W2109491705 @default.
• W2895474133 cites W2111294827 @default.
• W2895474133 cites W2115580899 @default.
• W2895474133 cites W2115630982 @default.
• W2895474133 cites W2117211286 @default.
• W2895474133 cites W2120515100 @default.
• W2895474133 cites W2120718999 @default.
• W2895474133 cites W2124114936 @default.
• W2895474133 cites W2131846297 @default.
• W2895474133 cites W2132173287 @default.
• W2895474133 cites W2133449490 @default.
• W2895474133 cites W2134280066 @default.
• W2895474133 cites W2135814503 @default.
• W2895474133 cites W2136820466 @default.
• W2895474133 cites W2139250164 @default.
• W2895474133 cites W2140230427 @default.
• W2895474133 cites W2169355315 @default.
• W2895474133 cites W2222641957 @default.
• W2895474133 cites W2277732086 @default.
• W2895474133 cites W2302524766 @default.
• W2895474133 cites W2518536270 @default.
• W2895474133 cites W2556485149 @default.
• W2895474133 cites W2583390195 @default.
• W2895474133 cites W2586226836 @default.
• W2895474133 cites W2593700719 @default.
• W2895474133 cites W2608670027 @default.
• W2895474133 cites W2618210811 @default.
• W2895474133 cites W2745643930 @default.
• W2895474133 cites W2759888013 @default.
• W2895474133 cites W2767209048 @default.
• W2895474133 cites W2770738300 @default.
• W2895474133 cites W2794108759 @default.
• W2895474133 cites W2802298459 @default.
• W2895474133 cites W2885704283 @default.
• W2895474133 doi "https://doi.org/10.1172/jci.insight.122673" @default.
• W2895474133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237480" @default.
• W2895474133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282829" @default.
• W2895474133 hasPublicationYear "2018" @default.

• next