Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895487417> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2895487417 endingPage "S291" @default.
- W2895487417 startingPage "S291" @default.
- W2895487417 abstract "Background: Laparoscopic cholecystectomy (LC) is the gold standard treatment in mild and moderate forms of acute calculous cholecystitis (ACC). Currently there is consensus for the use of antibiotics in the preoperative phase of ACC. However, the need for antibiotic therapy after surgery remains undefined with a low level of scientific evidence. Objective: To determine the effect of extended antibiotic therapy on infectious complications in patients with mild and moderate ACC undergoing LC. Methods: The CHART (Cholecystectomy Antibiotic Randomised Trial) study is a single-center, prospective, double blind, and randomized trial. Patients with mild to moderate ACC operated by laparoscopic cholecystectomy LC were randomly assigned to receive antibiotic (amoxicillin/clavulanic acid) or placebo treatment for 5 consecutive days. Primary endpoint was postoperative infectious complications. Secondary endpoints were as follows: (1) length of hospital stay, (2) readmissions, (3) reintervention and (4) mortality. Results: In the per-protocol analysis, 6 of 104 patients (5.8%) in the placebo arm and 6 of 91 patients (6.6%) in the antibiotic arm developed postoperative infectious complications, absolute difference 0.82 (95% CI, -5.96 to 7.61, p= 0.81). The median hospital stay was 3 days, without significant difference between groups (p= 0.3). There was no mortality. There were no differences regarding readmissions and reoperations between the two groups. Conclusions: The use of antibiotics in the postoperative period of laparoscopic cholecystectomy for mild and moderate acute calculous cholecystitis is not justified, since it was not associated with a decrease in the incidence of infectious and other types of morbidity in the present study." @default.
- W2895487417 created "2018-10-12" @default.
- W2895487417 creator A5001445844 @default.
- W2895487417 creator A5001643386 @default.
- W2895487417 creator A5006735847 @default.
- W2895487417 creator A5018164851 @default.
- W2895487417 creator A5040852361 @default.
- W2895487417 creator A5049133758 @default.
- W2895487417 creator A5049177641 @default.
- W2895487417 creator A5060222517 @default.
- W2895487417 creator A5080152849 @default.
- W2895487417 creator A5086307584 @default.
- W2895487417 date "2018-09-01" @default.
- W2895487417 modified "2023-10-18" @default.
- W2895487417 title "Extended antibiotic therapy versus placebo after laparoscopic cholecystectomy for mild and moderate acute calculous cholecystitis a randomized double-blind clinical trial" @default.
- W2895487417 doi "https://doi.org/10.1016/j.hpb.2018.06.274" @default.
- W2895487417 hasPublicationYear "2018" @default.
- W2895487417 type Work @default.
- W2895487417 sameAs 2895487417 @default.
- W2895487417 citedByCount "3" @default.
- W2895487417 countsByYear W28954874172020 @default.
- W2895487417 countsByYear W28954874172023 @default.
- W2895487417 crossrefType "journal-article" @default.
- W2895487417 hasAuthorship W2895487417A5001445844 @default.
- W2895487417 hasAuthorship W2895487417A5001643386 @default.
- W2895487417 hasAuthorship W2895487417A5006735847 @default.
- W2895487417 hasAuthorship W2895487417A5018164851 @default.
- W2895487417 hasAuthorship W2895487417A5040852361 @default.
- W2895487417 hasAuthorship W2895487417A5049133758 @default.
- W2895487417 hasAuthorship W2895487417A5049177641 @default.
- W2895487417 hasAuthorship W2895487417A5060222517 @default.
- W2895487417 hasAuthorship W2895487417A5080152849 @default.
- W2895487417 hasAuthorship W2895487417A5086307584 @default.
- W2895487417 hasBestOaLocation W28954874171 @default.
- W2895487417 hasConcept C120665830 @default.
- W2895487417 hasConcept C121332964 @default.
- W2895487417 hasConcept C141071460 @default.
- W2895487417 hasConcept C142724271 @default.
- W2895487417 hasConcept C168563851 @default.
- W2895487417 hasConcept C203092338 @default.
- W2895487417 hasConcept C204787440 @default.
- W2895487417 hasConcept C27081682 @default.
- W2895487417 hasConcept C2776641081 @default.
- W2895487417 hasConcept C2777148285 @default.
- W2895487417 hasConcept C2779454058 @default.
- W2895487417 hasConcept C2779708577 @default.
- W2895487417 hasConcept C2780354107 @default.
- W2895487417 hasConcept C501593827 @default.
- W2895487417 hasConcept C61511704 @default.
- W2895487417 hasConcept C71924100 @default.
- W2895487417 hasConcept C86803240 @default.
- W2895487417 hasConcept C89423630 @default.
- W2895487417 hasConceptScore W2895487417C120665830 @default.
- W2895487417 hasConceptScore W2895487417C121332964 @default.
- W2895487417 hasConceptScore W2895487417C141071460 @default.
- W2895487417 hasConceptScore W2895487417C142724271 @default.
- W2895487417 hasConceptScore W2895487417C168563851 @default.
- W2895487417 hasConceptScore W2895487417C203092338 @default.
- W2895487417 hasConceptScore W2895487417C204787440 @default.
- W2895487417 hasConceptScore W2895487417C27081682 @default.
- W2895487417 hasConceptScore W2895487417C2776641081 @default.
- W2895487417 hasConceptScore W2895487417C2777148285 @default.
- W2895487417 hasConceptScore W2895487417C2779454058 @default.
- W2895487417 hasConceptScore W2895487417C2779708577 @default.
- W2895487417 hasConceptScore W2895487417C2780354107 @default.
- W2895487417 hasConceptScore W2895487417C501593827 @default.
- W2895487417 hasConceptScore W2895487417C61511704 @default.
- W2895487417 hasConceptScore W2895487417C71924100 @default.
- W2895487417 hasConceptScore W2895487417C86803240 @default.
- W2895487417 hasConceptScore W2895487417C89423630 @default.
- W2895487417 hasLocation W28954874171 @default.
- W2895487417 hasOpenAccess W2895487417 @default.
- W2895487417 hasPrimaryLocation W28954874171 @default.
- W2895487417 hasRelatedWork W1992135923 @default.
- W2895487417 hasRelatedWork W2108363294 @default.
- W2895487417 hasRelatedWork W2167720717 @default.
- W2895487417 hasRelatedWork W2416300773 @default.
- W2895487417 hasRelatedWork W2621310438 @default.
- W2895487417 hasRelatedWork W3001512345 @default.
- W2895487417 hasRelatedWork W3199412420 @default.
- W2895487417 hasRelatedWork W4280514858 @default.
- W2895487417 hasRelatedWork W4386012285 @default.
- W2895487417 hasRelatedWork W3106869734 @default.
- W2895487417 hasVolume "20" @default.
- W2895487417 isParatext "false" @default.
- W2895487417 isRetracted "false" @default.
- W2895487417 magId "2895487417" @default.
- W2895487417 workType "article" @default.