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- W2895488468 abstract "Abstract Dopamine (DA) receptor and transporter dysfunctions play a major role in the pathophysiology of neuropsychiatric diseases including anxiety disorder (AD), major depressive disorder (MDD), bipolar disorder (BD) in the manic (BD man ) or depressive (BD dep ) state and schizophrenia (SZ). We performed a PUBMED search, which provided a total of 239 in vivo imaging studies with either positron emission tomography (PET) or single-proton emission computed tomography (SPECT). In these studies, DA transporter binding, D 1 receptor (R) binding, D 2 R binding, DA synthesis and/or DA release in patients with the primary diagnosis of acute AD (n=310), MDD (n=754), BD man (n=15), BD dep (n=49) or SZ (n=1532) were compared to healthy individuals. A retrospective analysis revealed that AD, MDD, BD man , BD dep and SZ differed as to affected brain region(s), affected synaptic constituent(s) and extent as well as direction of dysfunction in terms of either sensitization or desensitization of transporter and/or receptor binding sites. In contrast to AD and SZ, in MDD, BD man and BD dep , neostriatal DA function was normal, whereas MDD, BD man , and BD dep were characterized by the increased availability of prefrontal and frontal DA. In contrast to AD, MDD, BD man and BD dep , DA function in SZ was impaired throughout the nigrostriatal and mesolimbocortical system with an increased availability of DA in the striatothalamocortical and a decreased availability in the mesolimbocortical pathway." @default.
- W2895488468 created "2018-10-12" @default.
- W2895488468 creator A5017820157 @default.
- W2895488468 creator A5049887984 @default.
- W2895488468 creator A5064882474 @default.
- W2895488468 creator A5074439466 @default.
- W2895488468 date "2018-10-01" @default.
- W2895488468 modified "2023-10-14" @default.
- W2895488468 title "Acute anxiety disorder, major depressive disorder, bipolar disorder and schizophrenia are related to different patterns of nigrostriatal and mesolimbic dopamine dysfunction" @default.
- W2895488468 cites W114173899 @default.
- W2895488468 cites W1158934443 @default.
- W2895488468 cites W1479688563 @default.
- W2895488468 cites W1532478611 @default.
- W2895488468 cites W1603691909 @default.
- W2895488468 cites W162223338 @default.
- W2895488468 cites W1691520532 @default.
- W2895488468 cites W1934926274 @default.
- W2895488468 cites W1964177118 @default.
- W2895488468 cites W1966585596 @default.
- W2895488468 cites W1967460329 @default.
- W2895488468 cites W1969169028 @default.
- W2895488468 cites W1969844039 @default.
- W2895488468 cites W1970135881 @default.
- W2895488468 cites W1971855637 @default.
- W2895488468 cites W1972836962 @default.
- W2895488468 cites W1974105077 @default.
- W2895488468 cites W1976182760 @default.
- W2895488468 cites W1976435745 @default.
- W2895488468 cites W1977856078 @default.
- W2895488468 cites W1980894681 @default.
- W2895488468 cites W1981625862 @default.
- W2895488468 cites W1982091811 @default.
- W2895488468 cites W1982107302 @default.
- W2895488468 cites W1982429100 @default.
- W2895488468 cites W1982522250 @default.
- W2895488468 cites W1983616673 @default.
- W2895488468 cites W1983658264 @default.
- W2895488468 cites W1983776469 @default.
- W2895488468 cites W1984596181 @default.
- W2895488468 cites W1985652060 @default.
- W2895488468 cites W1986677503 @default.
- W2895488468 cites W1989180695 @default.
- W2895488468 cites W1991467174 @default.
- W2895488468 cites W1994978840 @default.
- W2895488468 cites W1996210781 @default.
- W2895488468 cites W1996327177 @default.
- W2895488468 cites W1996395211 @default.
- W2895488468 cites W1999520954 @default.
- W2895488468 cites W1999806798 @default.
- W2895488468 cites W2000647786 @default.
- W2895488468 cites W2004955328 @default.
- W2895488468 cites W2005146491 @default.
- W2895488468 cites W2005466129 @default.
- W2895488468 cites W2006122360 @default.
- W2895488468 cites W2009737020 @default.
- W2895488468 cites W2011222856 @default.
- W2895488468 cites W2012007142 @default.
- W2895488468 cites W2013793169 @default.
- W2895488468 cites W2015662187 @default.
- W2895488468 cites W2015796270 @default.
- W2895488468 cites W2016455950 @default.
- W2895488468 cites W2017421170 @default.
- W2895488468 cites W2018703700 @default.
- W2895488468 cites W2019399436 @default.
- W2895488468 cites W2020259690 @default.
- W2895488468 cites W2021006788 @default.
- W2895488468 cites W2022652429 @default.
- W2895488468 cites W2023193193 @default.
- W2895488468 cites W2024737755 @default.
- W2895488468 cites W2026764361 @default.
- W2895488468 cites W2027702949 @default.
- W2895488468 cites W2028864767 @default.
- W2895488468 cites W2029131420 @default.
- W2895488468 cites W2029343700 @default.
- W2895488468 cites W2029883023 @default.
- W2895488468 cites W2030148308 @default.
- W2895488468 cites W2030204209 @default.
- W2895488468 cites W2031696058 @default.
- W2895488468 cites W2032124712 @default.
- W2895488468 cites W2033825412 @default.
- W2895488468 cites W2034436110 @default.
- W2895488468 cites W2034545632 @default.
- W2895488468 cites W2035009272 @default.
- W2895488468 cites W2035686506 @default.
- W2895488468 cites W2036684254 @default.
- W2895488468 cites W2038106385 @default.
- W2895488468 cites W2038449957 @default.
- W2895488468 cites W2039630667 @default.
- W2895488468 cites W2040871293 @default.
- W2895488468 cites W2041166295 @default.
- W2895488468 cites W2042298460 @default.
- W2895488468 cites W2042301684 @default.
- W2895488468 cites W2042938639 @default.
- W2895488468 cites W2048024033 @default.
- W2895488468 cites W2048998525 @default.
- W2895488468 cites W2049426866 @default.
- W2895488468 cites W2050378039 @default.
- W2895488468 cites W2050823355 @default.