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- W2895510075 abstract "Immune recovery is a key factor in the management of patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study analyzed the factors contributing to immune reconstitution after allo-HSCT.Overall, 65 children with malignant or non-malignant diseases were included in multivariate analyses.The following factors contributed to a faster immune recovery: peripheral blood as a stem cell source and reactivation of CMV infection for CD3+ and CD4+ lymphocyte subpopulations; reactivation of CMV infection for CD8+ subset; donor EBV-IgG+ and no EBV reactivation for CD19 lymphocytes; recipient age below 10 years and peripheral blood as a stem cell source for NK cells. For CD2 and CD4/CD8 ratio no factor was significant in multivariate analysis.Patients receiving a graft from an EBV-IgG-positive donor and not having early EBV post-transplant viremia show faster recovery of the B-cells, while patients with early CMV-DNA-emia have a better re-establishment of T-cell subsets." @default.
- W2895510075 created "2018-10-12" @default.
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- W2895510075 date "2018-10-01" @default.
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- W2895510075 title "Impact of CMV and EBV on Immune Recovery After Allogeneic Hematopoietic Cell Transplantation in Children" @default.
- W2895510075 doi "https://doi.org/10.21873/anticanres.12950" @default.
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