Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895511223> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2895511223 endingPage "38" @default.
- W2895511223 startingPage "34" @default.
- W2895511223 abstract "Background Pulmonary arterial hypertension (PAH) is a progressive vascular disorder with a high mortality. Clinical experience and small case series suggest thrombocytopenia may be frequent in this population and associated with a poor prognosis. We sought to estimate the prevalence of thrombocytopenia in patients with PAH and characterize its association with disease characteristics and patient outcome. Methods Single center cohort study of 714 incident adult patients with Group 1 PH who were evaluated for baseline platelet count at the time of diagnosis. Pts were stratified into three groups: normal platelet count (>150 × 109/L), Grade 1 thrombocytopenia (75–149 × 109/L) and Grade 2–4 thrombocytopenia (<75 × 109/L). Results The median platelet count was 209 × 109/L (IQR 163, 264). There were 572 (80%) pts without thrombocytopenia, 107 (15%) with Grade 1 and 35 (5%) with Grade 2–4 thrombocytopenia. The median pt age was 55 years (IQR 44–65) with no difference between platelet groups (p = 0.85). Men were more likely to have thrombocytopenia (62, 34%) than women (80, 15%, p < 0.0001). Thrombocytopenia was frequent with portopulmonary PAH (84%) as opposed to idiopathic PAH (iPAH; 14%) or connective tissue disease associated PAH (12%). Platelet counts were not associated with functional class symptoms, the degree of right ventricular enlargement or dysfunction or tricuspid regurgitation by echocardiography. Invasive hemodynamics of right atrial pressure, mean pulmonary artery pressure and pulmonary vascular resistance were also similar between platelet groups. Thrombocytopenia was associated with higher mortality in iPAH patients (age- and sex-adjusted 5 year mortality [HR 1.95 (1.20, 3.08) p = 0.008] but not in other etiology groups. In a multivariate model of iPAH patients (adjusted for age, sex, DLCO, PVR, creatinine and 6MW distance) thrombocytopenia was most predictive of 5-year mortality [HR 1.68 (1.32, 2.12), p < 0.0001]. Conclusion Thrombocytopenia in the context of iPAH portends a poor prognosis and is a simple independent factor to consider in judging severity of disease." @default.
- W2895511223 created "2018-10-12" @default.
- W2895511223 creator A5002229961 @default.
- W2895511223 creator A5003786773 @default.
- W2895511223 creator A5006269991 @default.
- W2895511223 creator A5010482795 @default.
- W2895511223 creator A5061675548 @default.
- W2895511223 creator A5078732560 @default.
- W2895511223 creator A5081477279 @default.
- W2895511223 date "2019-01-01" @default.
- W2895511223 modified "2023-10-06" @default.
- W2895511223 title "Thrombocytopenia independently predicts death in idiopathic PAH" @default.
- W2895511223 cites W1968387663 @default.
- W2895511223 cites W1986229742 @default.
- W2895511223 cites W1991465354 @default.
- W2895511223 cites W2014166066 @default.
- W2895511223 cites W2017796110 @default.
- W2895511223 cites W2029438155 @default.
- W2895511223 cites W2035210659 @default.
- W2895511223 cites W2035384054 @default.
- W2895511223 cites W2059341870 @default.
- W2895511223 cites W2062627029 @default.
- W2895511223 cites W2102305061 @default.
- W2895511223 cites W2114374604 @default.
- W2895511223 cites W2114863766 @default.
- W2895511223 cites W2122700585 @default.
- W2895511223 cites W2140148084 @default.
- W2895511223 cites W2140319297 @default.
- W2895511223 cites W2313098007 @default.
- W2895511223 doi "https://doi.org/10.1016/j.hrtlng.2018.08.009" @default.
- W2895511223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301549" @default.
- W2895511223 hasPublicationYear "2019" @default.
- W2895511223 type Work @default.
- W2895511223 sameAs 2895511223 @default.
- W2895511223 citedByCount "11" @default.
- W2895511223 countsByYear W28955112232019 @default.
- W2895511223 countsByYear W28955112232020 @default.
- W2895511223 countsByYear W28955112232021 @default.
- W2895511223 countsByYear W28955112232022 @default.
- W2895511223 countsByYear W28955112232023 @default.
- W2895511223 crossrefType "journal-article" @default.
- W2895511223 hasAuthorship W2895511223A5002229961 @default.
- W2895511223 hasAuthorship W2895511223A5003786773 @default.
- W2895511223 hasAuthorship W2895511223A5006269991 @default.
- W2895511223 hasAuthorship W2895511223A5010482795 @default.
- W2895511223 hasAuthorship W2895511223A5061675548 @default.
- W2895511223 hasAuthorship W2895511223A5078732560 @default.
- W2895511223 hasAuthorship W2895511223A5081477279 @default.
- W2895511223 hasConcept C126322002 @default.
- W2895511223 hasConcept C164705383 @default.
- W2895511223 hasConcept C178853913 @default.
- W2895511223 hasConcept C2777214474 @default.
- W2895511223 hasConcept C2777728312 @default.
- W2895511223 hasConcept C2778808290 @default.
- W2895511223 hasConcept C2780930700 @default.
- W2895511223 hasConcept C2780940725 @default.
- W2895511223 hasConcept C2908647359 @default.
- W2895511223 hasConcept C58245268 @default.
- W2895511223 hasConcept C71924100 @default.
- W2895511223 hasConcept C72563966 @default.
- W2895511223 hasConcept C89560881 @default.
- W2895511223 hasConcept C90924648 @default.
- W2895511223 hasConcept C99454951 @default.
- W2895511223 hasConceptScore W2895511223C126322002 @default.
- W2895511223 hasConceptScore W2895511223C164705383 @default.
- W2895511223 hasConceptScore W2895511223C178853913 @default.
- W2895511223 hasConceptScore W2895511223C2777214474 @default.
- W2895511223 hasConceptScore W2895511223C2777728312 @default.
- W2895511223 hasConceptScore W2895511223C2778808290 @default.
- W2895511223 hasConceptScore W2895511223C2780930700 @default.
- W2895511223 hasConceptScore W2895511223C2780940725 @default.
- W2895511223 hasConceptScore W2895511223C2908647359 @default.
- W2895511223 hasConceptScore W2895511223C58245268 @default.
- W2895511223 hasConceptScore W2895511223C71924100 @default.
- W2895511223 hasConceptScore W2895511223C72563966 @default.
- W2895511223 hasConceptScore W2895511223C89560881 @default.
- W2895511223 hasConceptScore W2895511223C90924648 @default.
- W2895511223 hasConceptScore W2895511223C99454951 @default.
- W2895511223 hasIssue "1" @default.
- W2895511223 hasLocation W28955112231 @default.
- W2895511223 hasLocation W28955112232 @default.
- W2895511223 hasOpenAccess W2895511223 @default.
- W2895511223 hasPrimaryLocation W28955112231 @default.
- W2895511223 hasRelatedWork W1989937843 @default.
- W2895511223 hasRelatedWork W2150922388 @default.
- W2895511223 hasRelatedWork W2419627244 @default.
- W2895511223 hasRelatedWork W2469245272 @default.
- W2895511223 hasRelatedWork W2529035077 @default.
- W2895511223 hasRelatedWork W2770053528 @default.
- W2895511223 hasRelatedWork W3023279877 @default.
- W2895511223 hasRelatedWork W4291021631 @default.
- W2895511223 hasRelatedWork W4312767627 @default.
- W2895511223 hasRelatedWork W2254863832 @default.
- W2895511223 hasVolume "48" @default.
- W2895511223 isParatext "false" @default.
- W2895511223 isRetracted "false" @default.
- W2895511223 magId "2895511223" @default.
- W2895511223 workType "article" @default.