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• W2895511249 abstract "The purpose of this study was to prepare and characterize the microspheres of BBH (Berberine Hydrochloride) and TMP (Trimethoprim) by cross-linking Chitosan and sulfobutyl ether-β-cyclodextrin (SBE7-β-CD). TMP was first complexed with SBE7-β-CD, enhancing the solubility of TMP. then the blank microspheres was prepared by ionic gelation of Chitosan and SBE7-β-CD, and the formation conditions was determined, ranging from 1 mg mL−1 to 5 mg mL−1 Chitosan/SBE7-β-CD concentration and 1:0.5 to 1:1.5 Chitosan/SBE7-β-CD mass ratio. After then, the BBH/TMP microspheres were prepared by ionic gelation of TMP/SBE7-β-CD inclusion complex and Chitosan. The blank microspheres and the BBH/TMP microspheres were further confirmed by the FT-IR, DSC, particle size and zeta potential, the morphology studies was conducted by transmission electron microscope (TEM). The stability experiment show BBH/TMP microspheres were relatively stable at high temperature and strong illumination, but it would be preserved in good dry environment. The dissolution and the transdermal studies indicated that BBH/TMP microspheres possesses sustained release effect, and the antibacterial experiment in vitro also show that antibacterial effect of BBH/TMP microspheres occurred later than physical mixtures. In conclusion, all results indicate that prepared microspheres can be used as a promising vehicle for the encapsulation of BBH and TMP." @default.
• W2895511249 created "2018-10-12" @default.
• W2895511249 creator A5012590517 @default.
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• W2895511249 date "2018-12-01" @default.
• W2895511249 modified "2023-10-06" @default.
• W2895511249 title "Preparation and characterization of Berberine Hydrochloride and Trimethoprim Chitosan/ SBE7-β-CD microspheres" @default.
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• W2895511249 doi "https://doi.org/10.1016/j.jddst.2018.10.002" @default.
• W2895511249 hasPublicationYear "2018" @default.
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