Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895512571> ?p ?o ?g. }
- W2895512571 endingPage "389" @default.
- W2895512571 startingPage "378" @default.
- W2895512571 abstract "Abstract Purpose: Colorectal cancers with microsatellite instability–high (MSI-H) status, due to mismatch repair deficiency, are associated with poor patient outcomes after relapse. We aimed to identify novel therapeutic targets for them. Experimental Design: We performed MSI analyses of over 2,800 surgically resected colorectal tumors obtained from consecutive patients treated in Japan from 1998 through June 2016. Whole-exome sequencing, transcriptome sequencing, and methylation analyses were performed on 149 of 162 tumors showing MSI in BAT25 and BAT26 loci. We analyzed patient survival times using Bonferroni-adjusted log-rank tests. Results: Sporadic MSI-H colorectal cancers with promoter methylation of MLH1 (called MM) had a clinicopathological profile that was distinct from that of colorectal cancers of patients with germline mutations (Lynch syndrome, LS-associated) or somatic, Lynch-like mutations in mismatch repair genes. MM tumors had more insertions and deletions and more recurrent mutations in BRAF and RNF43 than LS-associated or Lynch-like MSI-H tumors. Eleven fusion kinases were exclusively detected in MM MSI-H colorectal cancers lacking oncogenic KRAS/BRAF missense mutations and were associated with worse post-relapse prognosis. We developed a simple method to identify MM tumors and applied it to a validation cohort of 28 MSI-H colorectal cancers, identifying 16 MM tumors and 2 fusion kinases. Conclusions: We discovered that fusion kinases are frequently observed among sporadic MM MSI-H colorectal cancers. The new method to identify MM tumors enables us to straightforwardly group MSI-H patients into candidates of LS or fusion kinase carriers." @default.
- W2895512571 created "2018-10-12" @default.
- W2895512571 creator A5001413231 @default.
- W2895512571 creator A5001514470 @default.
- W2895512571 creator A5002497469 @default.
- W2895512571 creator A5005708651 @default.
- W2895512571 creator A5010943454 @default.
- W2895512571 creator A5026151137 @default.
- W2895512571 creator A5027103782 @default.
- W2895512571 creator A5027839397 @default.
- W2895512571 creator A5028761902 @default.
- W2895512571 creator A5032033606 @default.
- W2895512571 creator A5053096878 @default.
- W2895512571 creator A5055021899 @default.
- W2895512571 creator A5055160098 @default.
- W2895512571 creator A5074950427 @default.
- W2895512571 creator A5078735893 @default.
- W2895512571 creator A5090361788 @default.
- W2895512571 creator A5090560513 @default.
- W2895512571 date "2019-01-01" @default.
- W2895512571 modified "2023-10-15" @default.
- W2895512571 title "Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers" @default.
- W2895512571 cites W1934094702 @default.
- W2895512571 cites W1965151932 @default.
- W2895512571 cites W1971000774 @default.
- W2895512571 cites W1973702005 @default.
- W2895512571 cites W1975784282 @default.
- W2895512571 cites W1995819860 @default.
- W2895512571 cites W2009720434 @default.
- W2895512571 cites W2015804539 @default.
- W2895512571 cites W2018368292 @default.
- W2895512571 cites W2022408375 @default.
- W2895512571 cites W2044386531 @default.
- W2895512571 cites W2044643325 @default.
- W2895512571 cites W2054621069 @default.
- W2895512571 cites W2074900147 @default.
- W2895512571 cites W2077059059 @default.
- W2895512571 cites W2077428590 @default.
- W2895512571 cites W2094390470 @default.
- W2895512571 cites W2102140136 @default.
- W2895512571 cites W2103441770 @default.
- W2895512571 cites W2107972234 @default.
- W2895512571 cites W2108851944 @default.
- W2895512571 cites W2122769974 @default.
- W2895512571 cites W2133465414 @default.
- W2895512571 cites W2137332694 @default.
- W2895512571 cites W2137779717 @default.
- W2895512571 cites W2140143664 @default.
- W2895512571 cites W2140320941 @default.
- W2895512571 cites W2141398932 @default.
- W2895512571 cites W2146772089 @default.
- W2895512571 cites W2155888371 @default.
- W2895512571 cites W2157852151 @default.
- W2895512571 cites W2158217645 @default.
- W2895512571 cites W2159064822 @default.
- W2895512571 cites W2168573309 @default.
- W2895512571 cites W2169903102 @default.
- W2895512571 cites W2262414037 @default.
- W2895512571 cites W2292803562 @default.
- W2895512571 cites W2303146341 @default.
- W2895512571 cites W2313308648 @default.
- W2895512571 cites W2547480541 @default.
- W2895512571 cites W2565185520 @default.
- W2895512571 cites W2569086487 @default.
- W2895512571 cites W2571705501 @default.
- W2895512571 doi "https://doi.org/10.1158/1078-0432.ccr-18-1574" @default.
- W2895512571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30279230" @default.
- W2895512571 hasPublicationYear "2019" @default.
- W2895512571 type Work @default.
- W2895512571 sameAs 2895512571 @default.
- W2895512571 citedByCount "49" @default.
- W2895512571 countsByYear W28955125712019 @default.
- W2895512571 countsByYear W28955125712020 @default.
- W2895512571 countsByYear W28955125712021 @default.
- W2895512571 countsByYear W28955125712022 @default.
- W2895512571 countsByYear W28955125712023 @default.
- W2895512571 crossrefType "journal-article" @default.
- W2895512571 hasAuthorship W2895512571A5001413231 @default.
- W2895512571 hasAuthorship W2895512571A5001514470 @default.
- W2895512571 hasAuthorship W2895512571A5002497469 @default.
- W2895512571 hasAuthorship W2895512571A5005708651 @default.
- W2895512571 hasAuthorship W2895512571A5010943454 @default.
- W2895512571 hasAuthorship W2895512571A5026151137 @default.
- W2895512571 hasAuthorship W2895512571A5027103782 @default.
- W2895512571 hasAuthorship W2895512571A5027839397 @default.
- W2895512571 hasAuthorship W2895512571A5028761902 @default.
- W2895512571 hasAuthorship W2895512571A5032033606 @default.
- W2895512571 hasAuthorship W2895512571A5053096878 @default.
- W2895512571 hasAuthorship W2895512571A5055021899 @default.
- W2895512571 hasAuthorship W2895512571A5055160098 @default.
- W2895512571 hasAuthorship W2895512571A5074950427 @default.
- W2895512571 hasAuthorship W2895512571A5078735893 @default.
- W2895512571 hasAuthorship W2895512571A5090361788 @default.
- W2895512571 hasAuthorship W2895512571A5090560513 @default.
- W2895512571 hasBestOaLocation W28955125712 @default.
- W2895512571 hasConcept C104317684 @default.
- W2895512571 hasConcept C111425858 @default.
- W2895512571 hasConcept C121608353 @default.