Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895513089> ?p ?o ?g. }
- W2895513089 endingPage "51" @default.
- W2895513089 startingPage "41" @default.
- W2895513089 abstract "Integrin-interacting protein Kindlin-2, as a focal adhesion protein, promotes growth and progression of breast cancer. However, the precise mechanism that underlie the role of Kindlin-2 in breast cancer is elusive. Here, we report that the expression of Kindlin-2 positively correlated with DNA methyltransferase 1(DNMT1) in breast cancer patients. Further, we found that DNMT1 was upregulated in mammary gland tissues of mammary specific Kindlin-2 transgenic mice. More importantly, high expression of DNMT1 was observed in mammary tumors formed by Kindlin-2 transgenic mice. On the basis of these observations, DNMT inhibitor 5-aza-CdR was used and found its treatment strongly decreased Kindlin-2-induced breast cancer cell proliferation and migration. Mechanistically, Kindlin-2 increased the stability of DNA methyltransferase DNMT1 through interaction with DNMT1 and methylated CpG islands in the E-cadherin promoter. Kindlin-2 increased the occupancy of DNMT1 at E-cadherin promoter, thereby suppressing E-cadherin expression. Taken together, our data reveal that Kindlin-2 promotes breast cancer development by enhancing the stability of DNMT1." @default.
- W2895513089 created "2018-10-12" @default.
- W2895513089 creator A5025314602 @default.
- W2895513089 creator A5029681475 @default.
- W2895513089 creator A5052541540 @default.
- W2895513089 creator A5062170722 @default.
- W2895513089 creator A5064055242 @default.
- W2895513089 creator A5070538645 @default.
- W2895513089 creator A5083581319 @default.
- W2895513089 creator A5086283662 @default.
- W2895513089 date "2018-12-01" @default.
- W2895513089 modified "2023-10-14" @default.
- W2895513089 title "Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development" @default.
- W2895513089 cites W1552528612 @default.
- W2895513089 cites W1651458958 @default.
- W2895513089 cites W1978252135 @default.
- W2895513089 cites W1987729382 @default.
- W2895513089 cites W1991463264 @default.
- W2895513089 cites W1991975849 @default.
- W2895513089 cites W1993547614 @default.
- W2895513089 cites W2002603913 @default.
- W2895513089 cites W2005532545 @default.
- W2895513089 cites W2013177752 @default.
- W2895513089 cites W2033525082 @default.
- W2895513089 cites W2034269086 @default.
- W2895513089 cites W2052267956 @default.
- W2895513089 cites W2053740346 @default.
- W2895513089 cites W2054244468 @default.
- W2895513089 cites W2058624823 @default.
- W2895513089 cites W2059587308 @default.
- W2895513089 cites W2068187102 @default.
- W2895513089 cites W2070136352 @default.
- W2895513089 cites W2070774814 @default.
- W2895513089 cites W2071121769 @default.
- W2895513089 cites W2071172965 @default.
- W2895513089 cites W2075214050 @default.
- W2895513089 cites W2084203180 @default.
- W2895513089 cites W2094038521 @default.
- W2895513089 cites W2102933980 @default.
- W2895513089 cites W2104546896 @default.
- W2895513089 cites W2109016302 @default.
- W2895513089 cites W2127865418 @default.
- W2895513089 cites W2137071178 @default.
- W2895513089 cites W2143375633 @default.
- W2895513089 cites W2151896857 @default.
- W2895513089 cites W2155554726 @default.
- W2895513089 cites W2232088318 @default.
- W2895513089 cites W2270895460 @default.
- W2895513089 cites W2286612125 @default.
- W2895513089 cites W2438426036 @default.
- W2895513089 cites W2465476568 @default.
- W2895513089 cites W2606262935 @default.
- W2895513089 cites W2726346047 @default.
- W2895513089 cites W2790001041 @default.
- W2895513089 doi "https://doi.org/10.1016/j.biocel.2018.09.022" @default.
- W2895513089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287284" @default.
- W2895513089 hasPublicationYear "2018" @default.
- W2895513089 type Work @default.
- W2895513089 sameAs 2895513089 @default.
- W2895513089 citedByCount "21" @default.
- W2895513089 countsByYear W28955130892019 @default.
- W2895513089 countsByYear W28955130892020 @default.
- W2895513089 countsByYear W28955130892021 @default.
- W2895513089 countsByYear W28955130892022 @default.
- W2895513089 countsByYear W28955130892023 @default.
- W2895513089 crossrefType "journal-article" @default.
- W2895513089 hasAuthorship W2895513089A5025314602 @default.
- W2895513089 hasAuthorship W2895513089A5029681475 @default.
- W2895513089 hasAuthorship W2895513089A5052541540 @default.
- W2895513089 hasAuthorship W2895513089A5062170722 @default.
- W2895513089 hasAuthorship W2895513089A5064055242 @default.
- W2895513089 hasAuthorship W2895513089A5070538645 @default.
- W2895513089 hasAuthorship W2895513089A5083581319 @default.
- W2895513089 hasAuthorship W2895513089A5086283662 @default.
- W2895513089 hasConcept C102230213 @default.
- W2895513089 hasConcept C104317684 @default.
- W2895513089 hasConcept C121608353 @default.
- W2895513089 hasConcept C1491633281 @default.
- W2895513089 hasConcept C149402561 @default.
- W2895513089 hasConcept C150194340 @default.
- W2895513089 hasConcept C175211621 @default.
- W2895513089 hasConcept C190727270 @default.
- W2895513089 hasConcept C2779979206 @default.
- W2895513089 hasConcept C502942594 @default.
- W2895513089 hasConcept C530470458 @default.
- W2895513089 hasConcept C54355233 @default.
- W2895513089 hasConcept C86803240 @default.
- W2895513089 hasConcept C95444343 @default.
- W2895513089 hasConceptScore W2895513089C102230213 @default.
- W2895513089 hasConceptScore W2895513089C104317684 @default.
- W2895513089 hasConceptScore W2895513089C121608353 @default.
- W2895513089 hasConceptScore W2895513089C1491633281 @default.
- W2895513089 hasConceptScore W2895513089C149402561 @default.
- W2895513089 hasConceptScore W2895513089C150194340 @default.
- W2895513089 hasConceptScore W2895513089C175211621 @default.
- W2895513089 hasConceptScore W2895513089C190727270 @default.
- W2895513089 hasConceptScore W2895513089C2779979206 @default.
- W2895513089 hasConceptScore W2895513089C502942594 @default.