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• W2895513420 startingPage "328" @default.
• W2895513420 abstract "The Hippo pathway plays a crucial role in organ size control and tumor suppression, but its precise regulation is not fully understood. In this study, we discovered that phosphatidic acid (PA)-related lipid signaling is a key regulator of the Hippo pathway. Supplementing PA in various Hippo-activating conditions activates YAP. This PA-related lipid signaling is involved in Rho-mediated YAP activation. Mechanistically, PA directly interacts with Hippo components LATS and NF2 to disrupt LATS-MOB1 complex formation and NF2-mediated LATS membrane translocation and activation, respectively. Inhibition of phospholipase D (PLD)-dependent PA production suppresses YAP oncogenic activities. PLD1 is highly expressed in breast cancer and positively correlates with YAP activation, suggesting their pathological relevance in breast cancer development. Taken together, our study not only reveals a role of PLD-PA lipid signaling in regulating the Hippo pathway but also indicates that the PLD-PA-YAP axis is a potential therapeutic target for cancer treatment." @default.
• W2895513420 created "2018-10-12" @default.
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• W2895513420 date "2018-10-01" @default.
• W2895513420 modified "2023-10-16" @default.
• W2895513420 title "Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction" @default.
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• W2895513420 doi "https://doi.org/10.1016/j.molcel.2018.08.038" @default.
• W2895513420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195446" @default.
• W2895513420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30293781" @default.
• W2895513420 hasPublicationYear "2018" @default.
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