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- W2895516069 abstract "This study aimed to assess the possible modulatory effect of nebivolol against methylprednisolone‐induced osteoporosis in rats. Weekly administration of methylprednisolone (7 mg/kg), for six consecutive weeks caused significant increases in serum calcium, bone malondialdehyde, and hydroxyproline as well as serum alkaline phosphatase, but it significantly decreased serum phosphorous and osteocalcin, bone reduced glutathione, and nitric oxide (NO) as well as bone antioxidant enzymes activities compared with the control group. The results were confirmed by histopathological findings of femur bone. On the other hand, administration of alendronate (1 mg/kg) with nebivolol (1.5 mg/kg) orally and daily for seven consecutive days after methylprednisolone treatment caused marked mitigation in the above‐mentioned parameters compared with methylprednisolone group. In conclusion, nebivolol proved to enhance the effect of alendronate in modulating methylprednisolone osteoporotic effect, which might be attributed to its release of NO together with its profound reducing capability in the oxidative cascade of bone tissue." @default.
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- W2895516069 date "2018-10-06" @default.
- W2895516069 modified "2023-09-26" @default.
- W2895516069 title "Nebivolol enhances the effect of alendronate against methylprednisolone‐induced osteoporosis in rats" @default.
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- W2895516069 doi "https://doi.org/10.1002/jbt.22232" @default.
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