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• W2895522803 abstract "M2 macrophages are characterized by high interleukin-10 (IL-10) expression and are critical for resolving inflammation. Although increased accumulation of M2 macrophages has been demonstrated in chronic rhinosinusitis with nasal polyps (CRSwNP), particularly the eosinophilic type, their functional relevance in CRSwNP remains poorly understood. M1 and M2 macrophages and IL-10 expression in sinonasal tissues were detected by double-immunofluorescence staining. THP-1 cells, a human monocytic leukemia cell line, were stimulated with various cytokines to study macrophage polarization and IL-10 expression. Polyp size, computed tomography (CT) scans, and symptom severity were scored. Compared with numbers in control tissues, the numbers of total CD68+ macrophages, interferon regulatory factor 5–positive and CD68+ M1 macrophages, and CD163+CD68+ and CD206+CD68+ M2 macrophages were increased in both eosinophilic and non-eosinophilic polyps. However, compared with non-eosinophilic polyps, eosinophilic polyps contained fewer M1 macrophages and more M2 macrophages. Consistent with this, the M1/M2 macrophage ratio was increased in non-eosinophilic polyps, whereas it decreased in eosinophilic polyps. Strikingly, the numbers of IL-10+CD68+ macrophages and the percentage of IL-10+CD68+ macrophages relative to the total number of macrophages were decreased in eosinophilic polyps, despite the upregulation of M2 macrophages in this type of polyp. The number of IL-10+CD68+ M2 macrophages correlated negatively with total symptoms scores, polyp sizes, total CT scores, and the total number of inflammatory cells in patients with eosinophilic CRSwNP. Poly I:C downregulated IL-10 expression in M2 macrophages differentiated from THP-1 cells in vitro. Impaired IL-10 production by M2 macrophages may contribute to sustained inflammation in eosinophilic CRSwNP.vv M2巨噬细胞高表达白细胞介素-10 (IL-10) , 在消退炎症中发挥重要作用。虽然CRSwNP尤其是嗜酸性粒细胞型鼻息肉被证实有M2巨噬细胞的明显聚集, 但是M2巨噬细胞在CRSwNP发挥的可能功能并不清楚。 双重免疫荧光染色技术用以检测鼻窦组织M1、M2巨噬细胞和IL-10的表达。培养人源性单核细胞白血病细胞系THP-1细胞, 用不同的细胞因子刺激THP-1细胞来研究巨噬细胞的极化和IL-10的表达情况。鼻息肉大小、CT及症状严重程度均记录评分 。 与正常对照组织相比, 嗜酸型及非嗜酸型鼻息肉组织中总CD68+巨噬细胞、干扰素调节因子5-阳性及CD68+M1巨噬细胞、CD163+CD68+、CD206+CD68+M2巨噬细胞细胞数均明显增加。但是, 与非嗜酸型鼻息肉相比, 嗜酸型鼻息肉M1巨噬细胞更少、M2巨噬细胞数较多。并且, M1/M2比值在非嗜酸型鼻息肉中更高。虽然嗜酸性粒细胞中M2巨噬细胞数更多, 但是其IL-10+CD68+巨噬细胞数、IL-10+CD68+巨噬细胞相对于总巨噬细胞数的比值比非嗜酸型鼻息肉者要低。嗜酸型CRSwNP患者IL-10+CD68+M2巨噬细胞数与总鼻症状评分、息肉大小、CT总分及炎性细胞总数负相关。THP-1细胞体外培养分化而来的M2巨噬细胞在接受Poly I:C刺激后IL-10表达水平下降。 M2巨噬细胞IL-10产生障碍可能参与嗜酸型CRSwNP持续炎症状态的维持。 Table S1. Demographic characteristics of the enrolled participants Table S2. Clinical characteristics of CRSwNP patients in immunohistochemistry and correlation study Table S3. Primary antibodies used in immunofluorescence staining Table S4. Primers used for quantitative PCR analysis Fig S1. Representative photomicrographs showing sinonasal tissue sections stained with control antibodies. Ig: immunoglobulin. Original magnification: × 400. Fig S2. Increased accumulation of CD206+CD68+ M2 macrophages predominantly in eosinophilic CRSwNP. Fig S3. Differentiation of M1 and M2 macrophages from THP-1 cells. Fig S4. Correlations of the number of CD206+CD68+ M2 macrophages with total symptom VAS scores, nasal polyp sizes, total CT scores, and total number of inflammatory cells in eosinophilic CRSwNP. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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• W2895522803 date "2018-10-03" @default.
• W2895522803 modified "2023-10-15" @default.
• W2895522803 title "Deficiency in interleukin-10 production by M2 macrophages in eosinophilic chronic rhinosinusitis with nasal polyps" @default.
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• W2895522803 doi "https://doi.org/10.1002/alr.22218" @default.
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