FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895523830> ?p ?o ?g. }

• W2895523830 endingPage "F1669" @default.
• W2895523830 startingPage "F1658" @default.
• W2895523830 abstract "Muscle dysfunction is an important cause of morbidity among patients with chronic kidney disease (CKD). Although muscle fibrosis is present in a CKD rodent model, its existence in humans and its impact on physical function are currently unknown. We examined isometric leg extension strength and measures of skeletal muscle fibrosis and inflammation in vastus lateralis muscle from CKD patients ( n = 10) and healthy, sedentary controls ( n = 10). Histochemistry and immunohistochemistry were used to assess muscle collagen and macrophage and fibro/adipogenic progenitor (FAP) cell populations, and RT-qPCR was used to assess muscle-specific inflammatory marker expression. Muscle collagen content was significantly greater in CKD compared with control (18.8 ± 2.1 vs. 11.7 ± 0.7% collagen area, P = 0.008), as was staining for collagen I, pro-collagen I, and a novel collagen-hybridizing peptide that binds remodeling collagen. Muscle collagen was inversely associated with leg extension strength in CKD ( r = −0.74, P = 0.01). FAP abundance was increased in CKD, was highly correlated with muscle collagen ( r = 0.84, P < 0.001), and was inversely associated with TNF-α expression ( r = −0.65, P = 0.003). TNF-α, CD68, CCL2, and CCL5 mRNA were significantly lower in CKD than control, despite higher serum TNF-α and IL-6. Immunohistochemistry confirmed fewer CD68+ and CD11b+ macrophages in CKD muscle. In conclusion, skeletal muscle collagen content is increased in humans with CKD and is associated with functional parameters. Muscle fibrosis correlated with increased FAP abundance, which may be due to insufficient macrophage-mediated TNF-α secretion. These data provide a foundation for future research elucidating the mechanisms responsible for this newly identified human muscle pathology." @default.
• W2895523830 created "2018-10-12" @default.
• W2895523830 creator A5000240586 @default.
• W2895523830 creator A5010536607 @default.
• W2895523830 creator A5020968199 @default.
• W2895523830 creator A5021812720 @default.
• W2895523830 creator A5025706604 @default.
• W2895523830 creator A5039934553 @default.
• W2895523830 creator A5048240153 @default.
• W2895523830 creator A5050771916 @default.
• W2895523830 creator A5050845958 @default.
• W2895523830 creator A5064501385 @default.
• W2895523830 creator A5073176660 @default.
• W2895523830 creator A5077728712 @default.
• W2895523830 creator A5082815889 @default.
• W2895523830 creator A5087260523 @default.
• W2895523830 date "2018-12-01" @default.
• W2895523830 modified "2023-10-16" @default.
• W2895523830 title "Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease" @default.
• W2895523830 cites W1540623806 @default.
• W2895523830 cites W1574278422 @default.
• W2895523830 cites W1964124818 @default.
• W2895523830 cites W1969811845 @default.
• W2895523830 cites W1974349202 @default.
• W2895523830 cites W1978958327 @default.
• W2895523830 cites W1979873217 @default.
• W2895523830 cites W1982174586 @default.
• W2895523830 cites W1987826116 @default.
• W2895523830 cites W1989052865 @default.
• W2895523830 cites W1993017805 @default.
• W2895523830 cites W1999902156 @default.
• W2895523830 cites W2000198481 @default.
• W2895523830 cites W2003903211 @default.
• W2895523830 cites W2004754771 @default.
• W2895523830 cites W2006318999 @default.
• W2895523830 cites W2010163891 @default.
• W2895523830 cites W2011781303 @default.
• W2895523830 cites W2012487210 @default.
• W2895523830 cites W2015411354 @default.
• W2895523830 cites W2016451005 @default.
• W2895523830 cites W2020506439 @default.
• W2895523830 cites W2030940155 @default.
• W2895523830 cites W2031815559 @default.
• W2895523830 cites W2037370931 @default.
• W2895523830 cites W2041426150 @default.
• W2895523830 cites W2043998851 @default.
• W2895523830 cites W2044361401 @default.
• W2895523830 cites W2052287604 @default.
• W2895523830 cites W2055348159 @default.
• W2895523830 cites W2057072817 @default.
• W2895523830 cites W2065241157 @default.
• W2895523830 cites W2065426370 @default.
• W2895523830 cites W2065629005 @default.
• W2895523830 cites W2076787014 @default.
• W2895523830 cites W2079799797 @default.
• W2895523830 cites W2080238836 @default.
• W2895523830 cites W2083970910 @default.
• W2895523830 cites W2084016324 @default.
• W2895523830 cites W2086124255 @default.
• W2895523830 cites W2086349792 @default.
• W2895523830 cites W2093274439 @default.
• W2895523830 cites W2102902846 @default.
• W2895523830 cites W2103933939 @default.
• W2895523830 cites W2115393877 @default.
• W2895523830 cites W2115438428 @default.
• W2895523830 cites W2115612732 @default.
• W2895523830 cites W2119156683 @default.
• W2895523830 cites W2121318575 @default.
• W2895523830 cites W2140056891 @default.
• W2895523830 cites W2140552765 @default.
• W2895523830 cites W2147015347 @default.
• W2895523830 cites W2148399278 @default.
• W2895523830 cites W2150951694 @default.
• W2895523830 cites W2151521311 @default.
• W2895523830 cites W2155965977 @default.
• W2895523830 cites W2156397323 @default.
• W2895523830 cites W2160966717 @default.
• W2895523830 cites W2161974326 @default.
• W2895523830 cites W2163182146 @default.
• W2895523830 cites W2164972088 @default.
• W2895523830 cites W2168524506 @default.
• W2895523830 cites W2169328204 @default.
• W2895523830 cites W2227260660 @default.
• W2895523830 cites W2439329172 @default.
• W2895523830 cites W2518756122 @default.
• W2895523830 cites W2538771555 @default.
• W2895523830 cites W2559920397 @default.
• W2895523830 cites W2601951312 @default.
• W2895523830 cites W2734527030 @default.
• W2895523830 cites W2735612938 @default.
• W2895523830 cites W2740642818 @default.
• W2895523830 cites W2751652417 @default.
• W2895523830 cites W2765327091 @default.
• W2895523830 cites W2769161682 @default.
• W2895523830 cites W2783663365 @default.
• W2895523830 cites W2790523548 @default.
• W2895523830 cites W4253550003 @default.
• W2895523830 doi "https://doi.org/10.1152/ajprenal.00314.2018" @default.

• next