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• W2895524535 startingPage "560" @default.
• W2895524535 abstract "Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue for the 21st century and is associated with significant liver-related morbidity and mortality. At present, there are no approved drug therapies for NASH. Consequently, NASH has become the focus of significant public and private research and development. In this review, we highlight the research and development (R&D) challenges and opportunities in this emerging therapeutic area. In particular, we consider the impact of the development of new biomarker strategies on clinical trial execution and design, and the positioning of single and combination therapies in future approaches to the treatment of NASH." @default.
• W2895524535 created "2018-10-12" @default.
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• W2895524535 date "2019-02-01" @default.
• W2895524535 modified "2023-09-25" @default.
• W2895524535 title "The future R&D landscape in non-alcoholic steatohepatitis (NASH)" @default.
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• W2895524535 doi "https://doi.org/10.1016/j.drudis.2018.09.020" @default.
• W2895524535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291900" @default.
• W2895524535 hasPublicationYear "2019" @default.
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