FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895526550> ?p ?o ?g. }

• W2895526550 abstract "Sapoviruses cause acute gastroenteritis in both humans and animals. However, the host signaling pathway(s) that facilitates host cell entry by sapoviruses remains largely unknown. Here we demonstrate that porcine sapovirus (PSaV) activates both PI3K/Akt and MEK/ERK cascades at an early stage of infection. Removal of cell surface receptors decreased PSaV-induced early activation of both cascades. Moreover, blocking of PI3K/Akt and MEK/ERK cascades entrapped PSaV particles in early endosomes and prevented their trafficking to the late endosomes. PSaV-induced early activation of PI3K and ERK molecules further mediated V-ATPase-dependent late endosomal acidification for PSaV uncoating. This work unravels a new mechanism by which receptor-mediated early activation of both cascades may facilitate PSaV trafficking from early to late endosomes and late endosomal acidification for PSaV uncoating, which in turn can be a new target for treatment of sapovirus infection." @default.
• W2895526550 created "2018-10-12" @default.
• W2895526550 creator A5001006216 @default.
• W2895526550 creator A5019134893 @default.
• W2895526550 creator A5034420811 @default.
• W2895526550 creator A5038598245 @default.
• W2895526550 creator A5041157506 @default.
• W2895526550 creator A5057927691 @default.
• W2895526550 creator A5060461427 @default.
• W2895526550 creator A5069215605 @default.
• W2895526550 creator A5075185165 @default.
• W2895526550 creator A5086680159 @default.
• W2895526550 creator A5087202678 @default.
• W2895526550 date "2018-12-15" @default.
• W2895526550 modified "2023-10-16" @default.
• W2895526550 title "Phosphatidylinositol 3-Kinase/Akt and MEK/ERK Signaling Pathways Facilitate Sapovirus Trafficking and Late Endosomal Acidification for Viral Uncoating in LLC-PK Cells" @default.
• W2895526550 cites W1505648210 @default.
• W2895526550 cites W1568605582 @default.
• W2895526550 cites W1570832747 @default.
• W2895526550 cites W1575798288 @default.
• W2895526550 cites W1917182292 @default.
• W2895526550 cites W1924246380 @default.
• W2895526550 cites W1930412321 @default.
• W2895526550 cites W1963666670 @default.
• W2895526550 cites W1964940884 @default.
• W2895526550 cites W1968435443 @default.
• W2895526550 cites W1969179779 @default.
• W2895526550 cites W1975220933 @default.
• W2895526550 cites W1981663661 @default.
• W2895526550 cites W1989950373 @default.
• W2895526550 cites W2002672965 @default.
• W2895526550 cites W2009076797 @default.
• W2895526550 cites W2015018931 @default.
• W2895526550 cites W2018893188 @default.
• W2895526550 cites W2019079607 @default.
• W2895526550 cites W2023930081 @default.
• W2895526550 cites W2026199442 @default.
• W2895526550 cites W2026867370 @default.
• W2895526550 cites W2028483614 @default.
• W2895526550 cites W2033785444 @default.
• W2895526550 cites W2049503434 @default.
• W2895526550 cites W2050028384 @default.
• W2895526550 cites W2052784514 @default.
• W2895526550 cites W2057818736 @default.
• W2895526550 cites W2059612298 @default.
• W2895526550 cites W2062840171 @default.
• W2895526550 cites W2072516412 @default.
• W2895526550 cites W2074340961 @default.
• W2895526550 cites W2082416335 @default.
• W2895526550 cites W2083701923 @default.
• W2895526550 cites W2086814394 @default.
• W2895526550 cites W2088046535 @default.
• W2895526550 cites W2090156287 @default.
• W2895526550 cites W2096374450 @default.
• W2895526550 cites W2100582497 @default.
• W2895526550 cites W2108571956 @default.
• W2895526550 cites W2110110363 @default.
• W2895526550 cites W2115151801 @default.
• W2895526550 cites W2135920412 @default.
• W2895526550 cites W2138355348 @default.
• W2895526550 cites W2138623102 @default.
• W2895526550 cites W2147259528 @default.
• W2895526550 cites W2152545790 @default.
• W2895526550 cites W2162936738 @default.
• W2895526550 cites W2166901919 @default.
• W2895526550 cites W2170200960 @default.
• W2895526550 cites W2170752267 @default.
• W2895526550 cites W2256756668 @default.
• W2895526550 cites W2269411538 @default.
• W2895526550 cites W2328968493 @default.
• W2895526550 cites W2508798274 @default.
• W2895526550 cites W2784018550 @default.
• W2895526550 cites W2794375041 @default.
• W2895526550 cites W2890343148 @default.
• W2895526550 doi "https://doi.org/10.1128/jvi.01674-18" @default.
• W2895526550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6258943" @default.
• W2895526550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282712" @default.
• W2895526550 hasPublicationYear "2018" @default.
• W2895526550 type Work @default.
• W2895526550 sameAs 2895526550 @default.
• W2895526550 citedByCount "7" @default.
• W2895526550 countsByYear W28955265502019 @default.
• W2895526550 countsByYear W28955265502020 @default.
• W2895526550 countsByYear W28955265502021 @default.
• W2895526550 crossrefType "journal-article" @default.
• W2895526550 hasAuthorship W2895526550A5001006216 @default.
• W2895526550 hasAuthorship W2895526550A5019134893 @default.
• W2895526550 hasAuthorship W2895526550A5034420811 @default.
• W2895526550 hasAuthorship W2895526550A5038598245 @default.
• W2895526550 hasAuthorship W2895526550A5041157506 @default.
• W2895526550 hasAuthorship W2895526550A5057927691 @default.
• W2895526550 hasAuthorship W2895526550A5060461427 @default.
• W2895526550 hasAuthorship W2895526550A5069215605 @default.
• W2895526550 hasAuthorship W2895526550A5075185165 @default.
• W2895526550 hasAuthorship W2895526550A5086680159 @default.
• W2895526550 hasAuthorship W2895526550A5087202678 @default.
• W2895526550 hasBestOaLocation W28955265501 @default.
• W2895526550 hasConcept C102747710 @default.
• W2895526550 hasConcept C184235292 @default.
• W2895526550 hasConcept C2780610907 @default.

• next