Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895529959> ?p ?o ?g. }
- W2895529959 endingPage "275" @default.
- W2895529959 startingPage "268" @default.
- W2895529959 abstract "An acetylcholinesterase inhibitory compound was isolated from Tephrosia purpurea (L.) Pers. by zebrafish brain based bioassay guided isolation and predicted as trans-tephrostachin.Enzyme kinetics studies (Line weaver-Burk plots and Michaelis Menten equation) favored the reversible / mixed type, with the inhibition constant (Ki) of 53.0 ± 7.4 μM in zebrafish brain (IC50 value of 39.0 ± 1.4 μM). However, the inhibition constant (Ki) was found to be 36.0 ± 0.4 μM with IC50 value of 20.0 ± 1.0 μM, whereas donepezil showed 3.2 ± 0.3 μM with the IC50 value of 0.12 ± 0.04 μM for human acetylcholinesterase. Further, the molecular docking, dynamics and simulation for trans-tephrostachin obtained better binding affinity and efficacy than commercial drugs donepezil and galanthamine. Hence, the isolated compound trans - tephrostachin from T. purpurea shall be further considered for the development of potential drug for the counteraction of Alzheimer's disease progression." @default.
- W2895529959 created "2018-10-12" @default.
- W2895529959 creator A5014603079 @default.
- W2895529959 creator A5019570423 @default.
- W2895529959 creator A5034557886 @default.
- W2895529959 creator A5079216837 @default.
- W2895529959 date "2018-11-01" @default.
- W2895529959 modified "2023-09-24" @default.
- W2895529959 title "Zebrafish bio-assay guided isolation of human acetylcholinesterase inhibitory trans-tephrostachin from Tephrosia purpurea (L.) Pers" @default.
- W2895529959 cites W1534454046 @default.
- W2895529959 cites W1971048984 @default.
- W2895529959 cites W1989753444 @default.
- W2895529959 cites W1989780429 @default.
- W2895529959 cites W1994417183 @default.
- W2895529959 cites W2003896813 @default.
- W2895529959 cites W2009973632 @default.
- W2895529959 cites W2010233441 @default.
- W2895529959 cites W2018724156 @default.
- W2895529959 cites W2021667660 @default.
- W2895529959 cites W2028332276 @default.
- W2895529959 cites W2033354781 @default.
- W2895529959 cites W2050324724 @default.
- W2895529959 cites W2060325210 @default.
- W2895529959 cites W2062385512 @default.
- W2895529959 cites W2072066516 @default.
- W2895529959 cites W2072320653 @default.
- W2895529959 cites W2073706909 @default.
- W2895529959 cites W2074076862 @default.
- W2895529959 cites W2083925455 @default.
- W2895529959 cites W2086273465 @default.
- W2895529959 cites W2093382813 @default.
- W2895529959 cites W2103945336 @default.
- W2895529959 cites W2120887653 @default.
- W2895529959 cites W2128049638 @default.
- W2895529959 cites W2128572087 @default.
- W2895529959 cites W2155039139 @default.
- W2895529959 cites W2170104881 @default.
- W2895529959 cites W2171268876 @default.
- W2895529959 cites W2333890525 @default.
- W2895529959 cites W2340910305 @default.
- W2895529959 cites W2426190620 @default.
- W2895529959 cites W2022462496 @default.
- W2895529959 doi "https://doi.org/10.1016/j.neulet.2018.09.058" @default.
- W2895529959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30290248" @default.
- W2895529959 hasPublicationYear "2018" @default.
- W2895529959 type Work @default.
- W2895529959 sameAs 2895529959 @default.
- W2895529959 citedByCount "7" @default.
- W2895529959 countsByYear W28955299592019 @default.
- W2895529959 countsByYear W28955299592020 @default.
- W2895529959 countsByYear W28955299592021 @default.
- W2895529959 countsByYear W28955299592022 @default.
- W2895529959 countsByYear W28955299592023 @default.
- W2895529959 crossrefType "journal-article" @default.
- W2895529959 hasAuthorship W2895529959A5014603079 @default.
- W2895529959 hasAuthorship W2895529959A5019570423 @default.
- W2895529959 hasAuthorship W2895529959A5034557886 @default.
- W2895529959 hasAuthorship W2895529959A5079216837 @default.
- W2895529959 hasConcept C104317684 @default.
- W2895529959 hasConcept C104488531 @default.
- W2895529959 hasConcept C126322002 @default.
- W2895529959 hasConcept C169760540 @default.
- W2895529959 hasConcept C17077164 @default.
- W2895529959 hasConcept C181199279 @default.
- W2895529959 hasConcept C185592680 @default.
- W2895529959 hasConcept C202751555 @default.
- W2895529959 hasConcept C2776878037 @default.
- W2895529959 hasConcept C2777752497 @default.
- W2895529959 hasConcept C2778816929 @default.
- W2895529959 hasConcept C2779059548 @default.
- W2895529959 hasConcept C2779134260 @default.
- W2895529959 hasConcept C2779483572 @default.
- W2895529959 hasConcept C2780904820 @default.
- W2895529959 hasConcept C41685203 @default.
- W2895529959 hasConcept C42972112 @default.
- W2895529959 hasConcept C54355233 @default.
- W2895529959 hasConcept C55493867 @default.
- W2895529959 hasConcept C71240020 @default.
- W2895529959 hasConcept C71924100 @default.
- W2895529959 hasConcept C86803240 @default.
- W2895529959 hasConcept C98274493 @default.
- W2895529959 hasConceptScore W2895529959C104317684 @default.
- W2895529959 hasConceptScore W2895529959C104488531 @default.
- W2895529959 hasConceptScore W2895529959C126322002 @default.
- W2895529959 hasConceptScore W2895529959C169760540 @default.
- W2895529959 hasConceptScore W2895529959C17077164 @default.
- W2895529959 hasConceptScore W2895529959C181199279 @default.
- W2895529959 hasConceptScore W2895529959C185592680 @default.
- W2895529959 hasConceptScore W2895529959C202751555 @default.
- W2895529959 hasConceptScore W2895529959C2776878037 @default.
- W2895529959 hasConceptScore W2895529959C2777752497 @default.
- W2895529959 hasConceptScore W2895529959C2778816929 @default.
- W2895529959 hasConceptScore W2895529959C2779059548 @default.
- W2895529959 hasConceptScore W2895529959C2779134260 @default.
- W2895529959 hasConceptScore W2895529959C2779483572 @default.
- W2895529959 hasConceptScore W2895529959C2780904820 @default.
- W2895529959 hasConceptScore W2895529959C41685203 @default.
- W2895529959 hasConceptScore W2895529959C42972112 @default.