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- W2895533093 abstract "Introduction: Hepatocyte growth factor (HGF) is a complete hepatic mitogen and is considered an initiator of liver regeneration. Liver regeneration following partical hepatectomy (PHx) is a complex process where liver sinusoidal endothelial cells (LSEC) play an important role. LSEC are regarded one of the most important liver cell types that produce HGF, but the exact contributions of LSEC to liver regeneration remain to be defined. Methods: To investigate the effects of hepatic angiocrine HGF signaling on liver regeneration, Stab2-Cretg/wt;HGFfl/fl (HGF-LSECKO) mice, where HGF is specifically knocked out in LSEC, were used. 70% PHx was performed on these mice and the kinetics of liver-to-body weight ratio, hepatocyte proliferation, HGF/c-MET signaling pathways and cell-cycle-associated genes were analyzed at different time points after PHx. Results: We found that HGF-LSECKO mice showed a significantly reduced liver-to-body weight ratio compared to the control group at 72 hours after PHx. HGF-LSECKO mice had a higer mortality after PHx and the proliferation of hepatocytes was significantly impaired at 48 hours after PHx in HGF-LSECKO mice. Conclusions: Hepatic angiocrine HGF signaling plays a vital role in the early stage of liver regeneration after PHx in mice. Hepatic angiocrine HGF signaling is not only essential for liver regeneration after injury, but also for the growth of the liver and even the whole organism." @default.
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- W2895533093 date "2018-09-01" @default.
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- W2895533093 title "Hepatic angiocrine HGF signaling plays a vital role in the early stage of liver regeneration after PHx in mice" @default.
- W2895533093 doi "https://doi.org/10.1016/j.hpb.2018.06.2946" @default.
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