FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895535287> ?p ?o ?g. }

• W2895535287 endingPage "10565" @default.
• W2895535287 startingPage "10552" @default.
• W2895535287 abstract "Scientists have hypothesized that the availability of phosphocreatine (PCr) and its ratio to inorganic phosphate (Pi) in cerebral tissue form a substrate of wakefulness. It follows then, according to this hypothesis, that the exhaustion of PCr and the decline in the ratio of PCr to Pi form a substrate of fatigue. We used 31P-magnetic resonance spectroscopy (31P-MRS) to investigate quantitative levels of PCr, the γ-signal of ATP, and Pi in 30 healthy humans (18 female) in the morning, in the afternoon, and while napping (n = 15) versus awake controls (n = 10). Levels of PCr (2.40 mM at 9 A.M.) decreased by 7.0 ± 0.8% (p = 7.1 × 10-6, t = -5.5) in the left thalamus between 9 A.M. and 5 P.M. Inversely, Pi (0.74 mM at 9 A.M.) increased by 17.1 ± 5% (p = 0.005, t = 3.1) and pH levels dropped by 0.14 ± 0.07 (p = 0.002; t = 3.6). Following a 20 min nap after 5 P.M., local PCr, Pi, and pH were restored to morning levels. We did not find respective significant changes in the contralateral thalamus or in other investigated brain regions. Left hemispheric PCr was signficantly lower than right hemispheric PCr only at 5 P.M. in the thalamus and at all conditions in the temporal region. Thus, cerebral daytime-related and sleep-related molecular changes are accessible in vivo Prominent changes were identified in the thalamus. This region is heavily relied on for a series of energy-consuming tasks, such as the relay of sensory information to the cortex. Furthermore, our data confirm that lateralization of brain function is regionally dynamic and includes PCr.SIGNIFICANCE STATEMENT The metabolites phosphocreatine (PCr) and inorganic phosphate (Pi) are assumed to inversely reflect the cellular energy load. This study detected a diurnal decrease of intracellular PCr and a nap-associated reincrease in the left thalamus. Pi behaved inversely. This outcome corroborates the role of the thalamus as a region of high energy consumption in agreement with its function as a gateway that relays and modulates information flow. Conversely to the dynamic lateralization of thalamic PCr, a constantly significant lateralization was observed in other regions. Increasing fatigue over the course of the day may also be a matter of cerebral energy supply. Comparatively fast restoration of that supply may be part of the biological basis for the recreational value of power napping." @default.
• W2895535287 created "2018-10-12" @default.
• W2895535287 creator A5011845725 @default.
• W2895535287 creator A5032129490 @default.
• W2895535287 creator A5033831142 @default.
• W2895535287 creator A5036945050 @default.
• W2895535287 creator A5037507176 @default.
• W2895535287 creator A5059553996 @default.
• W2895535287 creator A5090765536 @default.
• W2895535287 date "2018-10-03" @default.
• W2895535287 modified "2023-09-26" @default.
• W2895535287 title "Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap" @default.
• W2895535287 cites W107422749 @default.
• W2895535287 cites W1565036272 @default.
• W2895535287 cites W1589275161 @default.
• W2895535287 cites W1742132464 @default.
• W2895535287 cites W1849159432 @default.
• W2895535287 cites W1871073714 @default.
• W2895535287 cites W1964446668 @default.
• W2895535287 cites W1973117088 @default.
• W2895535287 cites W1973343893 @default.
• W2895535287 cites W1976843844 @default.
• W2895535287 cites W1980994010 @default.
• W2895535287 cites W1985527232 @default.
• W2895535287 cites W1986797937 @default.
• W2895535287 cites W1987177563 @default.
• W2895535287 cites W1987309757 @default.
• W2895535287 cites W1990082255 @default.
• W2895535287 cites W1990914851 @default.
• W2895535287 cites W1991304311 @default.
• W2895535287 cites W1996125945 @default.
• W2895535287 cites W2000693195 @default.
• W2895535287 cites W2003451199 @default.
• W2895535287 cites W2007261661 @default.
• W2895535287 cites W2008058077 @default.
• W2895535287 cites W2010119925 @default.
• W2895535287 cites W2010943643 @default.
• W2895535287 cites W2017725775 @default.
• W2895535287 cites W2018527646 @default.
• W2895535287 cites W2020696485 @default.
• W2895535287 cites W2031103319 @default.
• W2895535287 cites W2031722161 @default.
• W2895535287 cites W2035208729 @default.
• W2895535287 cites W2041316075 @default.
• W2895535287 cites W2047284216 @default.
• W2895535287 cites W2049471721 @default.
• W2895535287 cites W2052665207 @default.
• W2895535287 cites W2060611129 @default.
• W2895535287 cites W2067737347 @default.
• W2895535287 cites W2068212723 @default.
• W2895535287 cites W2069468777 @default.
• W2895535287 cites W2070003298 @default.
• W2895535287 cites W2090240067 @default.
• W2895535287 cites W2094080800 @default.
• W2895535287 cites W2094500507 @default.
• W2895535287 cites W2096887336 @default.
• W2895535287 cites W2100484765 @default.
• W2895535287 cites W2119428943 @default.
• W2895535287 cites W2125140103 @default.
• W2895535287 cites W2131373414 @default.
• W2895535287 cites W2135540697 @default.
• W2895535287 cites W2136022845 @default.
• W2895535287 cites W2147014254 @default.
• W2895535287 cites W2149746172 @default.
• W2895535287 cites W2161112423 @default.
• W2895535287 cites W2165892338 @default.
• W2895535287 cites W2166959979 @default.
• W2895535287 cites W2171090291 @default.
• W2895535287 cites W2236052756 @default.
• W2895535287 cites W2320141225 @default.
• W2895535287 cites W2461704772 @default.
• W2895535287 cites W2499584266 @default.
• W2895535287 cites W2501087139 @default.
• W2895535287 cites W2605030589 @default.
• W2895535287 cites W2606404075 @default.
• W2895535287 cites W4188528 @default.
• W2895535287 doi "https://doi.org/10.1523/jneurosci.0865-18.2018" @default.
• W2895535287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596250" @default.
• W2895535287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282723" @default.
• W2895535287 hasPublicationYear "2018" @default.
• W2895535287 type Work @default.
• W2895535287 sameAs 2895535287 @default.
• W2895535287 citedByCount "5" @default.
• W2895535287 countsByYear W28955352872019 @default.
• W2895535287 countsByYear W28955352872020 @default.
• W2895535287 countsByYear W28955352872021 @default.
• W2895535287 countsByYear W28955352872023 @default.
• W2895535287 crossrefType "journal-article" @default.
• W2895535287 hasAuthorship W2895535287A5011845725 @default.
• W2895535287 hasAuthorship W2895535287A5032129490 @default.
• W2895535287 hasAuthorship W2895535287A5033831142 @default.
• W2895535287 hasAuthorship W2895535287A5036945050 @default.
• W2895535287 hasAuthorship W2895535287A5037507176 @default.
• W2895535287 hasAuthorship W2895535287A5059553996 @default.
• W2895535287 hasAuthorship W2895535287A5090765536 @default.
• W2895535287 hasBestOaLocation W28955352871 @default.
• W2895535287 hasConcept C107513589 @default.
• W2895535287 hasConcept C121446783 @default.

• next