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- W2895537940 abstract "1858 CYR61 is a secreted, heparin-binding, extracellular matrix-associated angiogenic inducer. We have previously shown that CYR61 is involved in ovarian angiogenesis and that its expression is also detected in ovarian cancer cells. The goal of the present study was to determine the function(s) of CYR61 in ovarian tumor angiogenesis and progression. To accomplish this, we established stable CYR61 overexpressing OVCAR-5 clones along with appropriate pCDNA3.1 vector controls. Compared to parental OVCAR-5 and vector control cells, CYR61 stable clones exhibited a loss of cell-cell contact and an irregular cell morphology. These morphological changes were accompanied by increased mRNA expression of the epithelial-mesenchymal transition (EMT)-related transcription factors, Snail, Twist, and SIP1, but not of Slug. Western blotting of cell lysates demonstrated that CYR61 stable clones have significantly decreased (p" @default.
- W2895537940 created "2018-10-12" @default.
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- W2895537940 date "2006-04-15" @default.
- W2895537940 modified "2023-09-28" @default.
- W2895537940 title "A role for CYR61 in ovarian cancer progression" @default.
- W2895537940 hasPublicationYear "2006" @default.
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