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- W2895538508 abstract "Introduction: AJCC released the 8th edition of pancreatic cancer staging to be applied from 2018. The aim was to compare the 7th and 8th edition AJCC staging system for pancreatic cancer and to validate the 8th edition using a large multinational data. Method: Data of 2,864 patients with pancreatic ductal adenocarcinoma at the pancreas head were collected from Korea (571), Japan (824), and the USA (1,469). A survival analysis was performed to compare the 7th and the 8th editions. Validation of both editions was performed by log-rank tests and test for trend repeated 1,000 times with random validation sets. Results: In the 7th edition, 4.1%, 3.1%, 18.6%, 67.5%, 3.6%, and 3.1% of the patients were staged as IA, IB, IIA, IIB, III, and IV. In the 8th edition, 8.8% were IA, 13.9% IB, 3.1% IIA, 38.2% IIB, 32.9% III, and 3.1% IV. Down-staging of 459 patients occurred from IIA to the new IA and IB due to changes in the T classification. Upstaging of 856 patients occurred from the former IIB to III due to the new N2. The 7th edition mis-stratified IA and IB - IB showing better survival than IA. The 8th edition correctly stratifies the stages, but lacks discriminatory power between IB and IIA (p=0.271). Validation revealed that the 8th edition had a more correct and better stratification. Conclusions: The 8th edition AJCC staging system provides more even distribution of patients with a more powerful discrimination compared to the 7th edition for pancreas head cancer. Survival curves..." @default.
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- W2895538508 date "2018-09-01" @default.
- W2895538508 modified "2023-09-28" @default.
- W2895538508 title "Validation of AJCC 8th edition pancreatic cancer staging system using a large multinational data" @default.
- W2895538508 doi "https://doi.org/10.1016/j.hpb.2018.06.2011" @default.
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