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• W2895540533 startingPage "70" @default.
• W2895540533 abstract "The direct and indirect pathway striatal medium spiny neurons (dMSNs and iMSNs) have long been linked to action selection, but the precise roles of these neurons in this process remain unclear. Here, we review different models of striatal pathway function, focusing on the classic “go/no-go” model which posits that dMSNs facilitate movement while iMSNs inhibit movement, and the “complementary” model, which argues that dMSNs facilitate the selection of specific actions while iMSNs inhibit potentially conflicting actions. We discuss the merits and shortcomings of these models and propose a “competitive” model to explain the contribution of these two pathways to behavior. The “competitive” model argues that rather than inhibiting conflicting actions, iMSNs are tuned to the same actions that dMSNs facilitate, and the two populations “compete” to determine the animal’s behavioral response. This model provides a theoretical explanation for how these pathways work together to select actions. In addition, it provides a link between action selection and behavioral reinforcement, via modulating synaptic strength at inputs onto dMSNs and iMSNs. Finally, this model makes predictions about how imbalances in the activity of these pathways may underlie behavioral traits associated with psychiatric disorders. Understanding the roles of these striatal pathways in action selection may help to clarify the neuronal mechanisms of decision-making under normal and pathological conditions." @default.
• W2895540533 created "2018-10-12" @default.
• W2895540533 creator A5003406526 @default.
• W2895540533 creator A5061918050 @default.
• W2895540533 creator A5066225119 @default.
• W2895540533 creator A5075387929 @default.
• W2895540533 date "2019-06-01" @default.
• W2895540533 modified "2023-10-17" @default.
• W2895540533 title "A competitive model for striatal action selection" @default.
• W2895540533 cites W1014586844 @default.
• W2895540533 cites W1513230591 @default.
• W2895540533 cites W1806613378 @default.
• W2895540533 cites W1964962588 @default.
• W2895540533 cites W1965110331 @default.
• W2895540533 cites W1969591714 @default.
• W2895540533 cites W1971501199 @default.
• W2895540533 cites W1971797700 @default.
• W2895540533 cites W1971999279 @default.
• W2895540533 cites W1973399876 @default.
• W2895540533 cites W1977593923 @default.
• W2895540533 cites W1978625035 @default.
• W2895540533 cites W1980006923 @default.
• W2895540533 cites W1982827121 @default.
• W2895540533 cites W1982852470 @default.
• W2895540533 cites W1983398462 @default.
• W2895540533 cites W1989395462 @default.
• W2895540533 cites W1989915314 @default.
• W2895540533 cites W1991603311 @default.
• W2895540533 cites W1993774494 @default.
• W2895540533 cites W1996465982 @default.
• W2895540533 cites W2002800488 @default.
• W2895540533 cites W2002851360 @default.
• W2895540533 cites W2003314029 @default.
• W2895540533 cites W2005269174 @default.
• W2895540533 cites W2007727057 @default.
• W2895540533 cites W2011154084 @default.
• W2895540533 cites W2011223687 @default.
• W2895540533 cites W2011736950 @default.
• W2895540533 cites W2014756302 @default.
• W2895540533 cites W2015363601 @default.
• W2895540533 cites W2015701831 @default.
• W2895540533 cites W2017279410 @default.
• W2895540533 cites W2019982479 @default.
• W2895540533 cites W2022633426 @default.
• W2895540533 cites W2026982903 @default.
• W2895540533 cites W2028144985 @default.
• W2895540533 cites W2031170958 @default.
• W2895540533 cites W2034129279 @default.
• W2895540533 cites W2035590629 @default.
• W2895540533 cites W2036768211 @default.
• W2895540533 cites W2038010833 @default.
• W2895540533 cites W2039035354 @default.
• W2895540533 cites W2043292527 @default.
• W2895540533 cites W2046561631 @default.
• W2895540533 cites W2051284638 @default.
• W2895540533 cites W2055523610 @default.
• W2895540533 cites W2057029832 @default.
• W2895540533 cites W2057250808 @default.
• W2895540533 cites W2059243765 @default.
• W2895540533 cites W2059749451 @default.
• W2895540533 cites W2060588252 @default.
• W2895540533 cites W2068153172 @default.
• W2895540533 cites W2069437503 @default.
• W2895540533 cites W2070895732 @default.
• W2895540533 cites W2074651284 @default.
• W2895540533 cites W2076506821 @default.
• W2895540533 cites W2076759530 @default.
• W2895540533 cites W2079557795 @default.
• W2895540533 cites W2088134302 @default.
• W2895540533 cites W2088935470 @default.
• W2895540533 cites W2101640561 @default.
• W2895540533 cites W2103951007 @default.
• W2895540533 cites W2108743308 @default.
• W2895540533 cites W2109002457 @default.
• W2895540533 cites W2112648950 @default.
• W2895540533 cites W2117726420 @default.
• W2895540533 cites W2119035790 @default.
• W2895540533 cites W2129962758 @default.
• W2895540533 cites W2135090757 @default.
• W2895540533 cites W2141609201 @default.
• W2895540533 cites W2144572088 @default.
• W2895540533 cites W2145594774 @default.
• W2895540533 cites W2155505956 @default.
• W2895540533 cites W2165398609 @default.
• W2895540533 cites W2167021628 @default.
• W2895540533 cites W2168307317 @default.
• W2895540533 cites W2194584715 @default.
• W2895540533 cites W2233543443 @default.
• W2895540533 cites W2273816628 @default.
• W2895540533 cites W2309716161 @default.
• W2895540533 cites W2310417648 @default.
• W2895540533 cites W2344275832 @default.
• W2895540533 cites W2388891674 @default.
• W2895540533 cites W2396428346 @default.
• W2895540533 cites W2397032853 @default.
• W2895540533 cites W2406024906 @default.
• W2895540533 cites W2411645165 @default.
• W2895540533 cites W2417239685 @default.

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