FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895541619> ?p ?o ?g. }

• W2895541619 endingPage "153" @default.
• W2895541619 startingPage "145" @default.
• W2895541619 abstract "Regenerative medicine has a high demand for the development of scaffold materials combined with other osteogenic inducers to generate bioactive composite materials for bone replacement therapies. Previously, we reported that wedelolactone promoted osteoblastogenesis of bone marrow mesenchymal stem cells (BMSCs). In this study, the effect of hydroxyapatites (HAps), bone composite materials we prepared, and the combined effect of wedelolactone and HAps on osteoblastogenesis differentiation was first evaluated. Three kinds of HAps constructed by a rod-like shape with particle size of 25 nm (HAp-1), 37 nm (HAp-2), and 33 nm (HAp-3) did not affect BMSC survival, but induced activity of alkaline phosphatase(ALP), a marker enzyme for osteoblastogenesis. HAp-1 treatment resulted in a more significant increase in the number of ALP staining-positive BMSC, and maintained an extended time for the increased number of ALP staining-positive BMSC. Moreover, HAp-1 combined with wedelolactone induced a higher ALP activity for a longer time than HAp-2 and HAp-3, and also increased the bone mineralization level. Osteoblastogenesis-related marker genes expression including osteorix, osteocalcin, and runx2 were increased after BMSC were treated with HAp-1 for 6 days. Although three kinds of HAps treatment for 9 days increased osteorix mRNA expression, osteocalcin, and runx2 mRNA expression levels were upregulated only by HAp-1. Similarly, only HAp-1 enhanced wedelolactone-induced osteocalcin, osteorix, and runx2 mRNA expression after 9 days treatment. Together, these results suggested that HAps with different sizes generated different effect on osteoblastogenesis. HAp-1 combined with wedelolacone can exert an enhanced effect on osteoblastogenesis, which has potential for treating osteoporosis. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 145-153, 2019." @default.
• W2895541619 created "2018-10-12" @default.
• W2895541619 creator A5019179240 @default.
• W2895541619 creator A5032005332 @default.
• W2895541619 creator A5038468325 @default.
• W2895541619 creator A5042959555 @default.
• W2895541619 creator A5050462904 @default.
• W2895541619 creator A5068096080 @default.
• W2895541619 creator A5081200415 @default.
• W2895541619 date "2018-10-05" @default.
• W2895541619 modified "2023-10-11" @default.
• W2895541619 title "Effect of hydroxyapatite nanoparticles and wedelolactone on osteoblastogenesis from bone marrow mesenchymal stem cells" @default.
• W2895541619 cites W1742301767 @default.
• W2895541619 cites W1834113402 @default.
• W2895541619 cites W1976443161 @default.
• W2895541619 cites W1977671835 @default.
• W2895541619 cites W1993610595 @default.
• W2895541619 cites W2013100565 @default.
• W2895541619 cites W2014360106 @default.
• W2895541619 cites W2047654882 @default.
• W2895541619 cites W2052552951 @default.
• W2895541619 cites W2063584583 @default.
• W2895541619 cites W2067166922 @default.
• W2895541619 cites W2071567817 @default.
• W2895541619 cites W2074307364 @default.
• W2895541619 cites W2076020557 @default.
• W2895541619 cites W2097543492 @default.
• W2895541619 cites W2151030192 @default.
• W2895541619 cites W2153720415 @default.
• W2895541619 cites W2157396269 @default.
• W2895541619 cites W2206886257 @default.
• W2895541619 cites W2316199456 @default.
• W2895541619 cites W2510211208 @default.
• W2895541619 cites W2534241319 @default.
• W2895541619 cites W2621377986 @default.
• W2895541619 cites W2747222457 @default.
• W2895541619 cites W2750630633 @default.
• W2895541619 cites W2780315214 @default.
• W2895541619 cites W2789808608 @default.
• W2895541619 cites W2793486858 @default.
• W2895541619 cites W2801570645 @default.
• W2895541619 cites W2807611965 @default.
• W2895541619 cites W767206837 @default.
• W2895541619 doi "https://doi.org/10.1002/jbm.a.36541" @default.
• W2895541619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30289597" @default.
• W2895541619 hasPublicationYear "2018" @default.
• W2895541619 type Work @default.
• W2895541619 sameAs 2895541619 @default.
• W2895541619 citedByCount "10" @default.
• W2895541619 countsByYear W28955416192019 @default.
• W2895541619 countsByYear W28955416192020 @default.
• W2895541619 countsByYear W28955416192021 @default.
• W2895541619 countsByYear W28955416192022 @default.
• W2895541619 countsByYear W28955416192023 @default.
• W2895541619 crossrefType "journal-article" @default.
• W2895541619 hasAuthorship W2895541619A5019179240 @default.
• W2895541619 hasAuthorship W2895541619A5032005332 @default.
• W2895541619 hasAuthorship W2895541619A5038468325 @default.
• W2895541619 hasAuthorship W2895541619A5042959555 @default.
• W2895541619 hasAuthorship W2895541619A5050462904 @default.
• W2895541619 hasAuthorship W2895541619A5068096080 @default.
• W2895541619 hasAuthorship W2895541619A5081200415 @default.
• W2895541619 hasBestOaLocation W28955416191 @default.
• W2895541619 hasConcept C131075544 @default.
• W2895541619 hasConcept C153911025 @default.
• W2895541619 hasConcept C160160445 @default.
• W2895541619 hasConcept C181199279 @default.
• W2895541619 hasConcept C192562407 @default.
• W2895541619 hasConcept C198826908 @default.
• W2895541619 hasConcept C203014093 @default.
• W2895541619 hasConcept C2776363554 @default.
• W2895541619 hasConcept C2780007613 @default.
• W2895541619 hasConcept C2780804394 @default.
• W2895541619 hasConcept C2781460891 @default.
• W2895541619 hasConcept C28328180 @default.
• W2895541619 hasConcept C55493867 @default.
• W2895541619 hasConcept C86803240 @default.
• W2895541619 hasConcept C95444343 @default.
• W2895541619 hasConceptScore W2895541619C131075544 @default.
• W2895541619 hasConceptScore W2895541619C153911025 @default.
• W2895541619 hasConceptScore W2895541619C160160445 @default.
• W2895541619 hasConceptScore W2895541619C181199279 @default.
• W2895541619 hasConceptScore W2895541619C192562407 @default.
• W2895541619 hasConceptScore W2895541619C198826908 @default.
• W2895541619 hasConceptScore W2895541619C203014093 @default.
• W2895541619 hasConceptScore W2895541619C2776363554 @default.
• W2895541619 hasConceptScore W2895541619C2780007613 @default.
• W2895541619 hasConceptScore W2895541619C2780804394 @default.
• W2895541619 hasConceptScore W2895541619C2781460891 @default.
• W2895541619 hasConceptScore W2895541619C28328180 @default.
• W2895541619 hasConceptScore W2895541619C55493867 @default.
• W2895541619 hasConceptScore W2895541619C86803240 @default.
• W2895541619 hasConceptScore W2895541619C95444343 @default.
• W2895541619 hasFunder F4320321001 @default.
• W2895541619 hasIssue "1" @default.
• W2895541619 hasLocation W28955416191 @default.
• W2895541619 hasLocation W28955416192 @default.
• W2895541619 hasOpenAccess W2895541619 @default.

• next