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- W2895542542 abstract "Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NK cells in LPS-treated mice suppress clonal expansion of LCMV-specific CTLs by a NKG2D- or NCR1-independent but perforin-dependent mechanism. These results suggest a TLR4-mediated immunoregulatory role of NK cells during viral-bacterial coinfections." @default.
- W2895542542 created "2018-10-12" @default.
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- W2895542542 date "2018-10-08" @default.
- W2895542542 modified "2023-09-29" @default.
- W2895542542 title "Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells" @default.
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- W2895542542 doi "https://doi.org/10.1038/s41467-018-06609-z" @default.
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