FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895542940> ?p ?o ?g. }

• W2895542940 endingPage "12" @default.
• W2895542940 startingPage "1" @default.
• W2895542940 abstract "Lung cancer is among the most common malignancies with a poor 5-year survival rate reaching only 16%. Thus, new effective treatment modalities and drugs are urgently needed for the treatment of this malignancy. In this study, we conducted the first investigation of the effects of Biochanin A on lung cancer and revealed the mechanisms underlying its potential anticancer effects. Biochanin A decreased cell viability in a time-dependent and dose-dependent manner and suppressed colony formation in A549 and 95D cells. In addition, Biochanin A induced S phase arrest and apoptosis and decreased mitochondrial membrane potential (ΔΨm) in A549 and 95D cells in a dose-dependent manner. Our results of subcutaneous xenograft models showed that the growth of Biochanin A group was significantly inhibited compared with that of control groups. Finally, P21, Caspase-3, and Bcl-2 were activated in Biochanin A-treated cells and Biochanin A-treated xenografts which also demonstrated that Biochanin A induced cell cycle arrest and apoptosis in lung cancer cells by regulating expression of cell cycle-related proteins and apoptosis-related proteins. In conclusion, this study suggests that Biochanin A inhibits the proliferation of lung cancer cells and induces cell cycle arrest and apoptosis mainly by regulating cell cycle-related protein expression and activating the Bcl-2 and Caspase-3 pathways, thus suggesting that Biochanin A may be a promising drug to treat lung cancer." @default.
• W2895542940 created "2018-10-12" @default.
• W2895542940 creator A5005639902 @default.
• W2895542940 creator A5023636658 @default.
• W2895542940 creator A5028637363 @default.
• W2895542940 creator A5054785361 @default.
• W2895542940 creator A5070509406 @default.
• W2895542940 creator A5077171123 @default.
• W2895542940 date "2018-10-03" @default.
• W2895542940 modified "2023-10-16" @default.
• W2895542940 title "Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells" @default.
• W2895542940 cites W1797447800 @default.
• W2895542940 cites W1964483580 @default.
• W2895542940 cites W1971406206 @default.
• W2895542940 cites W1984164274 @default.
• W2895542940 cites W1985139403 @default.
• W2895542940 cites W1987792429 @default.
• W2895542940 cites W1992221542 @default.
• W2895542940 cites W1992708996 @default.
• W2895542940 cites W1994469480 @default.
• W2895542940 cites W2018439544 @default.
• W2895542940 cites W2018537155 @default.
• W2895542940 cites W2030122099 @default.
• W2895542940 cites W2030864103 @default.
• W2895542940 cites W2032003419 @default.
• W2895542940 cites W2038696352 @default.
• W2895542940 cites W2041679683 @default.
• W2895542940 cites W2045967803 @default.
• W2895542940 cites W2046025625 @default.
• W2895542940 cites W2054367080 @default.
• W2895542940 cites W2056064404 @default.
• W2895542940 cites W2091256192 @default.
• W2895542940 cites W2101995865 @default.
• W2895542940 cites W2109731526 @default.
• W2895542940 cites W2114781822 @default.
• W2895542940 cites W2119728044 @default.
• W2895542940 cites W2122589790 @default.
• W2895542940 cites W2136073669 @default.
• W2895542940 cites W2137493244 @default.
• W2895542940 cites W2157772417 @default.
• W2895542940 cites W2159048270 @default.
• W2895542940 cites W2164194457 @default.
• W2895542940 cites W2166810043 @default.
• W2895542940 cites W2233325915 @default.
• W2895542940 cites W83647411 @default.
• W2895542940 doi "https://doi.org/10.1155/2018/3545376" @default.
• W2895542940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192129" @default.
• W2895542940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30402472" @default.
• W2895542940 hasPublicationYear "2018" @default.
• W2895542940 type Work @default.
• W2895542940 sameAs 2895542940 @default.
• W2895542940 citedByCount "23" @default.
• W2895542940 countsByYear W28955429402019 @default.
• W2895542940 countsByYear W28955429402020 @default.
• W2895542940 countsByYear W28955429402021 @default.
• W2895542940 countsByYear W28955429402022 @default.
• W2895542940 countsByYear W28955429402023 @default.
• W2895542940 crossrefType "journal-article" @default.
• W2895542940 hasAuthorship W2895542940A5005639902 @default.
• W2895542940 hasAuthorship W2895542940A5023636658 @default.
• W2895542940 hasAuthorship W2895542940A5028637363 @default.
• W2895542940 hasAuthorship W2895542940A5054785361 @default.
• W2895542940 hasAuthorship W2895542940A5070509406 @default.
• W2895542940 hasAuthorship W2895542940A5077171123 @default.
• W2895542940 hasBestOaLocation W28955429401 @default.
• W2895542940 hasConcept C105696609 @default.
• W2895542940 hasConcept C121608353 @default.
• W2895542940 hasConcept C126322002 @default.
• W2895542940 hasConcept C1491633281 @default.
• W2895542940 hasConcept C190283241 @default.
• W2895542940 hasConcept C2776256026 @default.
• W2895542940 hasConcept C2778298627 @default.
• W2895542940 hasConcept C2778821405 @default.
• W2895542940 hasConcept C2780955279 @default.
• W2895542940 hasConcept C29537977 @default.
• W2895542940 hasConcept C502942594 @default.
• W2895542940 hasConcept C55493867 @default.
• W2895542940 hasConcept C62112901 @default.
• W2895542940 hasConcept C71924100 @default.
• W2895542940 hasConcept C86803240 @default.
• W2895542940 hasConceptScore W2895542940C105696609 @default.
• W2895542940 hasConceptScore W2895542940C121608353 @default.
• W2895542940 hasConceptScore W2895542940C126322002 @default.
• W2895542940 hasConceptScore W2895542940C1491633281 @default.
• W2895542940 hasConceptScore W2895542940C190283241 @default.
• W2895542940 hasConceptScore W2895542940C2776256026 @default.
• W2895542940 hasConceptScore W2895542940C2778298627 @default.
• W2895542940 hasConceptScore W2895542940C2778821405 @default.
• W2895542940 hasConceptScore W2895542940C2780955279 @default.
• W2895542940 hasConceptScore W2895542940C29537977 @default.
• W2895542940 hasConceptScore W2895542940C502942594 @default.
• W2895542940 hasConceptScore W2895542940C55493867 @default.
• W2895542940 hasConceptScore W2895542940C62112901 @default.
• W2895542940 hasConceptScore W2895542940C71924100 @default.
• W2895542940 hasConceptScore W2895542940C86803240 @default.
• W2895542940 hasLocation W28955429401 @default.
• W2895542940 hasLocation W28955429402 @default.
• W2895542940 hasLocation W28955429403 @default.

• next