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- W2895543401 abstract "Aim: We aim to evaluate the prognostic Hong Kong Liver Cancer (HKLC) classification scheme in an Indian context by applying it to patients undergoing surgery for HCC at Tata Memorial Hospital. Methods: 102 patients of HCC who underwent surgery at Tata memorial hospital, from Dec 2010 to June 2015 were evaluated. The HKLC classification was compared with the Barcelona Clinic Liver Cancer (BCLC) classification in terms of discriminatory ability and effectiveness of treatment recommendation. Results and discussion: Out of 102 patients who underwent surgical intervention, 23 were HKLC stage 1, 64 were HKLC stage 2 and 12 belonged to HKLC stage 3. HKLC identified subsets of BCLC intermediate- and advanced-stage patients for more aggressive treatments which improved our survival outcomes., BCLC-B patients who were classified as HKLC-2, the survival benefit of radical surgery, compared with transarterial chemoembolization, was substantial (5-year survival probability, 77.1 % v/s 18.7% reported in literature). BCLC-C patients who were classified as HKLC-3, the survival benefit of surgical excision compared with systemic therapy was even more pronounced (5-year survival probability, 66.3%% v/s 0.0%). At a median follow up of 35 months, the estimated 5 year DFS was 25% and OS was 74% across all the surgical resected patients. Conclusions: In the Indian setting with more patients presenting with larger tumors but with good child status, surgery remains a feasible option even though they fall out of BCLC criteria for operability. Outcomes of these patients validate HKLC as a more pragmatic scoring system in the Indian context." @default.
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- W2895543401 date "2018-09-01" @default.
- W2895543401 modified "2023-10-16" @default.
- W2895543401 title "Evaluation of Hong Kong liver cancer (HKLC) classification for hepatocellular carcinoma (HCC) patients undergoing surgical resection at tertiary care cancer centre in India" @default.
- W2895543401 doi "https://doi.org/10.1016/j.hpb.2018.06.2674" @default.
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