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- W2895544006 abstract "Two pairs of enantiomers, (−) and (+)-securidanes A ( 1 and 2 ) and B ( 3 and 4 ) featuring unprecedented triarylmethane (TAM) skeletons, were isolated from Securidaca inappendiculata . Their structures were established by spectroscopic data, X-ray crystallography, and CD analysis. A plausible biosynthetic pathway for 1 − 4 based on the co-isolated precursors was proposed. Bioinspired total synthesis of 1 − 4 was completed in high yield, which in turn corroborated the biosynthetic hypothesis. Compounds 1 − 4 showed good inhibition against protein tyrosine phosphatase 1B (PTP1B). The molecular docking demonstrated that the strongest inhibitor 3 (IC 50 = 7.52 μ M) reaches deeper into the binding pocket and has an additional H-bond." @default.
- W2895544006 created "2018-10-12" @default.
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- W2895544006 date "2018-01-01" @default.
- W2895544006 modified "2023-09-22" @default.
- W2895544006 title "(−)- and (+)-Securidanes A and B, Natural Triarylmethane Enantiomers: Structure and Bioinspired Total Synthesis" @default.
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- W2895544006 doi "https://doi.org/10.1155/2018/2674182" @default.
- W2895544006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6750104" @default.
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