Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895546893> ?p ?o ?g. }
- W2895546893 abstract "Abstract Porphyromonas gingivalis is a keystone bacterial pathogen of chronic periodontitis. P . gingivalis is unable to synthesise the porphyrin macrocycle and relies on exogenous porphyrin, including haem or haem biosynthesis intermediates from host sources. We show that under the iron-limited conditions prevailing in tissue environments, P . gingivalis expresses a haemophore-like protein, HusA, to mediate the uptake of essential porphyrin and support pathogen survival within epithelial cells. The structure of HusA, together with titration studies, mutagenesis and in silico docking, show that haem binds in a hydrophobic groove on the α-helical structure without the typical iron coordination seen in other haemophores. This mode of interaction allows HusA to bind to a variety of abiotic and metal-free porphyrins with higher affinities than to haem. We exploit this unusual porphyrin-binding activity of HusA to target a prototypic deuteroporphyrin-metronidazole conjugate with restricted antimicrobial specificity in a Trojan horse strategy that effectively kills intracellular P. gingivalis ." @default.
- W2895546893 created "2018-10-12" @default.
- W2895546893 creator A5025867911 @default.
- W2895546893 creator A5026815496 @default.
- W2895546893 creator A5027980673 @default.
- W2895546893 creator A5033787418 @default.
- W2895546893 creator A5041630117 @default.
- W2895546893 creator A5041735063 @default.
- W2895546893 creator A5056353600 @default.
- W2895546893 creator A5060425100 @default.
- W2895546893 creator A5063097307 @default.
- W2895546893 creator A5063383602 @default.
- W2895546893 creator A5079354767 @default.
- W2895546893 creator A5088109464 @default.
- W2895546893 creator A5091787727 @default.
- W2895546893 date "2018-10-05" @default.
- W2895546893 modified "2023-09-26" @default.
- W2895546893 title "Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis" @default.
- W2895546893 cites W1504095541 @default.
- W2895546893 cites W1566515137 @default.
- W2895546893 cites W1946679064 @default.
- W2895546893 cites W1969164033 @default.
- W2895546893 cites W1976126861 @default.
- W2895546893 cites W1980732767 @default.
- W2895546893 cites W1983702221 @default.
- W2895546893 cites W1989272792 @default.
- W2895546893 cites W1999564887 @default.
- W2895546893 cites W2001718113 @default.
- W2895546893 cites W2009798288 @default.
- W2895546893 cites W2012385987 @default.
- W2895546893 cites W2014239094 @default.
- W2895546893 cites W2015094506 @default.
- W2895546893 cites W2020498316 @default.
- W2895546893 cites W2023384179 @default.
- W2895546893 cites W2024916880 @default.
- W2895546893 cites W2027548893 @default.
- W2895546893 cites W2035525047 @default.
- W2895546893 cites W2037723468 @default.
- W2895546893 cites W2040874215 @default.
- W2895546893 cites W2043248182 @default.
- W2895546893 cites W2045666433 @default.
- W2895546893 cites W2050090579 @default.
- W2895546893 cites W2062819146 @default.
- W2895546893 cites W2077124327 @default.
- W2895546893 cites W2081626827 @default.
- W2895546893 cites W2086953830 @default.
- W2895546893 cites W2101673942 @default.
- W2895546893 cites W2109652055 @default.
- W2895546893 cites W2118049844 @default.
- W2895546893 cites W2129779380 @default.
- W2895546893 cites W2134967712 @default.
- W2895546893 cites W2135211971 @default.
- W2895546893 cites W2136646476 @default.
- W2895546893 cites W2138814013 @default.
- W2895546893 cites W2143996952 @default.
- W2895546893 cites W2145947173 @default.
- W2895546893 cites W2147979587 @default.
- W2895546893 cites W2152859518 @default.
- W2895546893 cites W2167491944 @default.
- W2895546893 cites W2169678694 @default.
- W2895546893 cites W2262430119 @default.
- W2895546893 cites W2340425772 @default.
- W2895546893 cites W2562205137 @default.
- W2895546893 cites W2591462746 @default.
- W2895546893 cites W2747992112 @default.
- W2895546893 cites W2766578585 @default.
- W2895546893 doi "https://doi.org/10.1038/s41467-018-06470-0" @default.
- W2895546893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173696" @default.
- W2895546893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30291238" @default.
- W2895546893 hasPublicationYear "2018" @default.
- W2895546893 type Work @default.
- W2895546893 sameAs 2895546893 @default.
- W2895546893 citedByCount "27" @default.
- W2895546893 countsByYear W28955468932019 @default.
- W2895546893 countsByYear W28955468932020 @default.
- W2895546893 countsByYear W28955468932021 @default.
- W2895546893 countsByYear W28955468932022 @default.
- W2895546893 countsByYear W28955468932023 @default.
- W2895546893 crossrefType "journal-article" @default.
- W2895546893 hasAuthorship W2895546893A5025867911 @default.
- W2895546893 hasAuthorship W2895546893A5026815496 @default.
- W2895546893 hasAuthorship W2895546893A5027980673 @default.
- W2895546893 hasAuthorship W2895546893A5033787418 @default.
- W2895546893 hasAuthorship W2895546893A5041630117 @default.
- W2895546893 hasAuthorship W2895546893A5041735063 @default.
- W2895546893 hasAuthorship W2895546893A5056353600 @default.
- W2895546893 hasAuthorship W2895546893A5060425100 @default.
- W2895546893 hasAuthorship W2895546893A5063097307 @default.
- W2895546893 hasAuthorship W2895546893A5063383602 @default.
- W2895546893 hasAuthorship W2895546893A5079354767 @default.
- W2895546893 hasAuthorship W2895546893A5088109464 @default.
- W2895546893 hasAuthorship W2895546893A5091787727 @default.
- W2895546893 hasBestOaLocation W28955468931 @default.
- W2895546893 hasConcept C159110408 @default.
- W2895546893 hasConcept C181199279 @default.
- W2895546893 hasConcept C185592680 @default.
- W2895546893 hasConcept C2776217839 @default.
- W2895546893 hasConcept C2776460866 @default.
- W2895546893 hasConcept C2779480358 @default.
- W2895546893 hasConcept C2780014169 @default.