Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895550542> ?p ?o ?g. }
- W2895550542 abstract "Significance Cerebellins are important neurexin ligands that remain poorly understood. Two critical questions in particular remain unanswered: do different cerebellins perform distinct functions, and do these functions act in the initial establishment of synapses or in rendering nascent synapses capable of normal synaptic transmission? Here we report that in mice, two homologous cerebellins, Cbln2 and Cbln4, are expressed in different types of neurons of the medial habenula (MHb), and that these neurons project to distinct target neurons in the interpeduncular nucleus. Ablation of Cbln2 or Cbln4 from the MHb impairs distinct behaviors, but only ablation of Cbln2 affects synapse numbers. Our data show that different cerebellins perform distinct functions that involve synaptic information processing but not initial synapse formation." @default.
- W2895550542 created "2018-10-12" @default.
- W2895550542 creator A5041115024 @default.
- W2895550542 creator A5065929776 @default.
- W2895550542 date "2018-10-04" @default.
- W2895550542 modified "2023-09-27" @default.
- W2895550542 title "Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs" @default.
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- W2895550542 doi "https://doi.org/10.1073/pnas.1811086115" @default.
- W2895550542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205418" @default.
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