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• W2895554838 abstract "130 antenatal women with singleton gestation with high riskfactors for preterm labour were enrolled in the study. Primigravidacomprise 20% of study group, rest being constituted by mutigravidwomen. Major proportion of antenatal women in study population werein age group 20-24 years.Among the study group,35.3 % (n-46) had history of priorspontaneous preterm birth.11 women had associated risk factors forpreterm labour such as spontaneous or induced first trimester abortion,interpregnancy interval more than 5 years, mullerian anomaly.46.9% of study population had history of two or more firsttrimester abortion, either spontaneous or induced and 27 women had coexisting risk factors such as second trimester abortion,(n-10)prior onespontaneous preterm birth, interpregnancy interval more than 59months, evidence of infection such as periodontal disease and urinary tractinfection. 20 % of women among study group had history of threatenedmiscarriage.53% of women had sonographic estimation of cervical lengthless than 25 mm. 46.9% of women had cervical length more than 25 mm.63.7% of women with short cervix had preterm delivery.When mode of delivery is considered, 82% of womendelivered by labour natural. 6% had instrumental delivery, 3% hadassisted breech delivery and 9% were delivered by caesarean section.50.7 % of babies were of low birth weight.(n-66).63% of preterm babieshad NICU admission compared to 4.4 % of term babies.Among the study group, occurrence of preterm birth was more inwomen with BMI less than 20 followed by women with BMI 20 -25among whom the incidence of preterm birth was 44.3 %.Antenatal women in age group less than 20 had highestoccurrence of preterm delivery, followed by women in age group 20-24years who had 52 % preterm birth.The sensitivity and specificity of cervical length estimated bytransvaginal sonography was 70.9% and 63.2% respectively in predictionof preterm birth in women at high risk for preterm labour.Regarding the validity of test, positive predictive value was 63.7 %in prediction of preterm labour in women with high risk factors.70.9% ofwomen with cervical length more than 25 mm had termdelivery,i.e,negative predictive value of the test was 70.5%.Hence, transvaginal sonographic estimation of cervical length has afairly accurate sensitivity and specificity in prediction of preterm labourin women with high risk factors such as prior spontaneous preterm birth,prior first trimester, second trimester miscarriage, threatened miscarriage.Validity of test as reinforced by good negative predictive value suggeststhat it can be used as a screening test in prediction of preterm birth inwomen with singleton gestation and having high risk factor for pretermlabour.CONCLUSIONPreterm delivery has significant contribution to perinatalmortality, infant death and morbidity ranging from cerebral palsy tochronic lung disease. Prediction and prevention is imperative thancontrol. Medical, educational loss, economic cost, social burden onindividual and families necessitate reduction in preterm birth.Numerous biomarkers are under research of which few areunder vogue. Their efficacy, cut off value need to be standardized byfurther studies. Transvaginal sonographic determination of cervical lengthin women with singleton pregnancy and high risk for preterm labour is auseful screening tool for prediction of preterm labour.Recent studies including those by Fonseca et al, have shown theefficacy of progesterone in reducing preterm labour in women with pasthistory of preterm birth, to which sonographic short cervix adds valueby proper selection of cases.Compared to biomarkers, transvaginal sonographic cervicallength measurement is less expensive, easily accessible, objective,reproducible, acceptable to the patient and can be combined with routine anomaly scan in women with risk factors for preterm labour." @default.
• W2895554838 created "2018-10-12" @default.
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• W2895554838 date "2013-04-01" @default.
• W2895554838 modified "2023-09-27" @default.
• W2895554838 title "Transvaginal Ultrasonographic assessment of cervical length in predicting preterm labour in high risk asymptomatic women with singleton gestation" @default.
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