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• W2895555849 endingPage "165" @default.
• W2895555849 startingPage "165" @default.
• W2895555849 abstract "Hepatitis C virus (HCV) represents a challenging global health threat to ~200 million infected individuals. Clinical data suggest that only ~10–15% of acutely HCV-infected individuals will achieve spontaneous viral clearance despite exuberant virus-specific immune responses, which is largely attributed to difficulties in recognizing the pathognomonic symptoms during the initial stages of exposure to the virus. Given the paucity of a suitable small animal model, it is also equally challenging to study the early phases of viral establishment. Further, the host factors contributing to HCV chronicity in a vast majority of acutely HCV-infected individuals largely remain unexplored. The last few years have witnessed a surge in studies showing that HCV adopts myriad mechanisms to disconcert virus-specific immune responses in the host to establish persistence, which includes, but is not limited to viral escape mutations, viral growth at privileged sites, and antagonism. Here we discuss a few hitherto poorly explained mechanisms employed by HCV that are believed to lead to chronicity in infected individuals. A better understanding of these mechanisms would aid the design of improved therapeutic targets against viral establishment in susceptible individuals." @default.
• W2895555849 created "2018-10-12" @default.
• W2895555849 creator A5001481428 @default.
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• W2895555849 creator A5086368104 @default.
• W2895555849 date "2018-10-12" @default.
• W2895555849 modified "2023-09-26" @default.
• W2895555849 title "Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion" @default.
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• W2895555849 doi "https://doi.org/10.3390/cells7100165" @default.
• W2895555849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6210370" @default.
• W2895555849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30322028" @default.
• W2895555849 hasPublicationYear "2018" @default.

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