FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895557117> ?p ?o ?g. }

• W2895557117 abstract "Chronic active Epstein-Barr virus (EBV) infection (CAEBV) of the T-/NK-cell type, systemic form is a rare and potentially life-threatening illness caused by persistent EBV infection. The highest incidence is found in children and adolescents with increased frequency among Asians and Native Americans, while the disease is uncommon in Western countries. Typically patients present with unspecific symptoms, like fever, lymphadenopathy, hepatosplenomegaly and liver dysfunction. Due to fatal complications including hemophagocytic syndrome, coagulopathy, multiple organ failure and development of EBV-positive lymphoproliferative disease (LPD) or lymphoma early diagnosis is critical for successful treatment. However, in consequence of the lack of experience due to the low incidence in Europe, a broad spectrum of clinical manifestations and a particularly unexpected group of patients, diagnosis can be challenging. Inhere we describe the clinicopathological findings of an African adult with CAEBV associated LPD with a brief review of the literature. A 42-year-old African man with fever, enlargement of the spleen and a suspected epileptic seizure was referred to our hospital. Diagnostic testing repeatedly revealed a massive EBV-DNA load in peripheral blood. Whole-body PET-CT-scan presented a strong uptake at multiple bone marrow sites, the thyroid and the adrenal glands. Histopathological analysis of bone marrow and thyroid gland revealed a highly proliferating, atypical and predominantly intravascular cytotoxic T-cell population with intracellular EBV-encoded RNA. Clonality analysis revealed the presence of polyclonal T-cell-receptor. Based on these findings a CAEBV of the T-/NK-cell type, systemic form was diagnosed. Subsequent therapy including three cycles of chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisolone resulted in decreased EBV load, clinical improvement and ongoing complete remission. Adult-onset CAEBV of T/NK-cell type usually comprises a poor prognosis and is extremely rare in Western countries. Therefore, our case highlights the need for a clinical awareness of this disease in patients with systemic illness and for a comprehensive multidisciplinary diagnostic approach to facilitate diagnosis. Treatment options include antiviral drugs, immunosuppressive agents and systemic chemotherapy with or without allogeneic stem cell transplantation. Given the limited data these options need to be decided upon in each patient individually considering severity of the disease, comorbidities and response." @default.
• W2895557117 created "2018-10-12" @default.
• W2895557117 creator A5001414926 @default.
• W2895557117 creator A5008484624 @default.
• W2895557117 creator A5009769102 @default.
• W2895557117 creator A5063231601 @default.
• W2895557117 creator A5076453948 @default.
• W2895557117 creator A5084079017 @default.
• W2895557117 creator A5084826011 @default.
• W2895557117 date "2018-10-03" @default.
• W2895557117 modified "2023-10-16" @default.
• W2895557117 title "Chronic active Epstein-Barr virus infection of T-cell type, systemic form in an African migrant: case report and review of the literature on diagnostics standards and therapeutic options" @default.
• W2895557117 cites W2031423829 @default.
• W2895557117 cites W2045994384 @default.
• W2895557117 cites W2052425622 @default.
• W2895557117 cites W2073631928 @default.
• W2895557117 cites W2093709330 @default.
• W2895557117 cites W2094342081 @default.
• W2895557117 cites W2102579193 @default.
• W2895557117 cites W2148927501 @default.
• W2895557117 cites W2154227505 @default.
• W2895557117 cites W2310716991 @default.
• W2895557117 cites W2589130275 @default.
• W2895557117 cites W2613412745 @default.
• W2895557117 cites W2621422844 @default.
• W2895557117 doi "https://doi.org/10.1186/s12885-018-4861-0" @default.
• W2895557117 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6169008" @default.
• W2895557117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30285657" @default.
• W2895557117 hasPublicationYear "2018" @default.
• W2895557117 type Work @default.
• W2895557117 sameAs 2895557117 @default.
• W2895557117 citedByCount "5" @default.
• W2895557117 countsByYear W28955571172019 @default.
• W2895557117 countsByYear W28955571172020 @default.
• W2895557117 countsByYear W28955571172021 @default.
• W2895557117 countsByYear W28955571172022 @default.
• W2895557117 crossrefType "journal-article" @default.
• W2895557117 hasAuthorship W2895557117A5001414926 @default.
• W2895557117 hasAuthorship W2895557117A5008484624 @default.
• W2895557117 hasAuthorship W2895557117A5009769102 @default.
• W2895557117 hasAuthorship W2895557117A5063231601 @default.
• W2895557117 hasAuthorship W2895557117A5076453948 @default.
• W2895557117 hasAuthorship W2895557117A5084079017 @default.
• W2895557117 hasAuthorship W2895557117A5084826011 @default.
• W2895557117 hasBestOaLocation W28955571171 @default.
• W2895557117 hasConcept C126322002 @default.
• W2895557117 hasConcept C142724271 @default.
• W2895557117 hasConcept C203014093 @default.
• W2895557117 hasConcept C2779134260 @default.
• W2895557117 hasConcept C2779338263 @default.
• W2895557117 hasConcept C2779440204 @default.
• W2895557117 hasConcept C2908647359 @default.
• W2895557117 hasConcept C526584372 @default.
• W2895557117 hasConcept C71924100 @default.
• W2895557117 hasConcept C99454951 @default.
• W2895557117 hasConceptScore W2895557117C126322002 @default.
• W2895557117 hasConceptScore W2895557117C142724271 @default.
• W2895557117 hasConceptScore W2895557117C203014093 @default.
• W2895557117 hasConceptScore W2895557117C2779134260 @default.
• W2895557117 hasConceptScore W2895557117C2779338263 @default.
• W2895557117 hasConceptScore W2895557117C2779440204 @default.
• W2895557117 hasConceptScore W2895557117C2908647359 @default.
• W2895557117 hasConceptScore W2895557117C526584372 @default.
• W2895557117 hasConceptScore W2895557117C71924100 @default.
• W2895557117 hasConceptScore W2895557117C99454951 @default.
• W2895557117 hasIssue "1" @default.
• W2895557117 hasLocation W28955571171 @default.
• W2895557117 hasLocation W28955571172 @default.
• W2895557117 hasLocation W28955571173 @default.
• W2895557117 hasLocation W28955571174 @default.
• W2895557117 hasOpenAccess W2895557117 @default.
• W2895557117 hasPrimaryLocation W28955571171 @default.
• W2895557117 hasRelatedWork W2056639682 @default.
• W2895557117 hasRelatedWork W2060762604 @default.
• W2895557117 hasRelatedWork W2123644273 @default.
• W2895557117 hasRelatedWork W2135842842 @default.
• W2895557117 hasRelatedWork W2188369799 @default.
• W2895557117 hasRelatedWork W2409757718 @default.
• W2895557117 hasRelatedWork W2415604070 @default.
• W2895557117 hasRelatedWork W2568885592 @default.
• W2895557117 hasRelatedWork W2748952813 @default.
• W2895557117 hasRelatedWork W4323838250 @default.
• W2895557117 hasVolume "18" @default.
• W2895557117 isParatext "false" @default.
• W2895557117 isRetracted "false" @default.
• W2895557117 magId "2895557117" @default.
• W2895557117 workType "article" @default.