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• W2895564148 abstract "The common marmoset ( Callithrix jacchus ) is uniquely suited for longitudinal studies of cognitive aging, due to a relatively short lifespan, sophisticated cognitive abilities, and patterns of brain aging that resemble those of humans. We examined cognitive function and fine motor skills in male and female marmosets (mean age ∼5 at study entry) followed longitudinally for 2 years. Each year, monkeys were tested on a reversal learning task with three pairs of stimuli ( n = 18, 9 females) and a fine motor task requiring them to grasp small rewards from two staircases (Hill and Valley test, n = 12, 6 females). There was little evidence for a decline in cognitive flexibility between the two time points, in part because of practice effects. However, independent of year of testing, females took longer than males to reach criterion in the reversals, indicating impaired cognitive flexibility. Motivation was unlikely to contribute to this effect, as males refused a greater percentage of trials than females in the reversals. With regards to motor function, females were significantly faster than males in the Hill and Valley task. From Year 1 to Year 2, a slight slowing of motor function was observed in both sexes, but accuracy decreased significantly in males only. This study (1) demonstrates that marmosets exhibit sex differences in cognitive flexibility and fine motor function that resemble those described in humans; (2) that changes in fine motor function can already be detected at middle‐age; and (3) that males may experience greater age‐related changes in fine motor skills than females. Additional data points will determine whether these sex and age differences persist over time." @default.
• W2895564148 created "2018-10-12" @default.
• W2895564148 creator A5009758181 @default.
• W2895564148 creator A5037370723 @default.
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• W2895564148 creator A5077435578 @default.
• W2895564148 date "2018-10-03" @default.
• W2895564148 modified "2023-10-15" @default.
• W2895564148 title "One‐year change in cognitive flexibility and fine motor function in middle‐aged male and female marmosets (<i>Callithrix jacchus</i>)" @default.
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• W2895564148 doi "https://doi.org/10.1002/ajp.22924" @default.
• W2895564148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6816503" @default.
• W2895564148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30281810" @default.
• W2895564148 hasPublicationYear "2018" @default.
• W2895564148 type Work @default.
• W2895564148 sameAs 2895564148 @default.

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