Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895568417> ?p ?o ?g. }
- W2895568417 endingPage "730" @default.
- W2895568417 startingPage "722" @default.
- W2895568417 abstract "This work deals with development of polyfunctional biocompatible cationic surfactant systems based on bioactive saturated bicyclic alkaloid quinuclidine. It is focused on the effect of the chemical structure of surfactants on their aggregation behavior, their physicochemical estimation of solubility of model water insoluble dye Orange OT and drugs, quercetin and rutin, microbiology and cytotoxicity. Quaternary ammonium derivatives of quinuclidine (Q-Nuc-n) with different hydrophobicity (R = CnH2n+1, where n = 14, 16, 18) were synthesized. Self-assembly of Q-Nuc-n was investigated by tensiometry, conductometry, spectrophotometry, fluorimetry and dynamic light scattering. The critical micelle concentration, thermodynamic and adsorption parameters at water-air interface, size and aggregation numbers of Q-Nuc-n micelles were determined. The looser packing of surfactant molecules in Q-Nuc-n micelles compared to its analogues, quaternized derivatives of 1,4‑diazabicyclo[2.2.2]octane (DABCO-n), was established. The hydrophobic dye Orange OT and drugs quercetin and rutin were solubilized in micellar Q-Nuc-n solutions better than in solutions of classical surfactant CTAB and its analogue DABCO-n. Solubilization capacity of Q-Nuc-18 is 5 times higher than that of classical surfactant CTAB. Q-Nuc-18 1.95 μg·mL−1 has also bactericidal and fungicidal activity 2 times (against S. aureus 209P) and 8 times (against B. cereus 8035) higher than antibiotics Norfloxacin and antifungal Ketoconazole. Q-Nuc-16 has the highest bactericidal activity. It is 6 times (against S. aureus 209P) and 15 times (against B. cereus 8035) higher than the bactericidal activity value of Norfloxacin. Synthesized cationic surfactants based on quinuclidine are new multifunctional biocompatible compounds with high potential in nanomedicine and biotechnology." @default.
- W2895568417 created "2018-10-12" @default.
- W2895568417 creator A5017395617 @default.
- W2895568417 creator A5030140325 @default.
- W2895568417 creator A5057984118 @default.
- W2895568417 creator A5068243422 @default.
- W2895568417 creator A5072472271 @default.
- W2895568417 creator A5076489975 @default.
- W2895568417 creator A5085140054 @default.
- W2895568417 creator A5087792094 @default.
- W2895568417 creator A5089778549 @default.
- W2895568417 date "2018-12-01" @default.
- W2895568417 modified "2023-10-15" @default.
- W2895568417 title "Synthesis, biological evaluation and structure-activity relationships of self-assembled and solubilization properties of amphiphilic quaternary ammonium derivatives of quinuclidine" @default.
- W2895568417 cites W1964086751 @default.
- W2895568417 cites W1968218268 @default.
- W2895568417 cites W1974596054 @default.
- W2895568417 cites W1974655820 @default.
- W2895568417 cites W1979684471 @default.
- W2895568417 cites W1982640631 @default.
- W2895568417 cites W1983366658 @default.
- W2895568417 cites W1983690785 @default.
- W2895568417 cites W1990586218 @default.
- W2895568417 cites W1990864447 @default.
- W2895568417 cites W1991980674 @default.
- W2895568417 cites W1993053769 @default.
- W2895568417 cites W1994003100 @default.
- W2895568417 cites W2006461924 @default.
- W2895568417 cites W2008511442 @default.
- W2895568417 cites W2015356274 @default.
- W2895568417 cites W2020132018 @default.
- W2895568417 cites W2025894932 @default.
- W2895568417 cites W2033923037 @default.
- W2895568417 cites W2047007696 @default.
- W2895568417 cites W2050884917 @default.
- W2895568417 cites W2051303390 @default.
- W2895568417 cites W2052200284 @default.
- W2895568417 cites W2083422792 @default.
- W2895568417 cites W2085911180 @default.
- W2895568417 cites W2085921260 @default.
- W2895568417 cites W2093486399 @default.
- W2895568417 cites W2145291609 @default.
- W2895568417 cites W2149356982 @default.
- W2895568417 cites W2163197158 @default.
- W2895568417 cites W2203487456 @default.
- W2895568417 cites W2234991034 @default.
- W2895568417 cites W2316699502 @default.
- W2895568417 cites W2326425741 @default.
- W2895568417 cites W2414721313 @default.
- W2895568417 cites W2481456751 @default.
- W2895568417 cites W2547412077 @default.
- W2895568417 cites W2554518393 @default.
- W2895568417 cites W2605657683 @default.
- W2895568417 cites W2613371607 @default.
- W2895568417 cites W2646348380 @default.
- W2895568417 cites W2724419348 @default.
- W2895568417 cites W2742051806 @default.
- W2895568417 cites W2756767585 @default.
- W2895568417 cites W2764224989 @default.
- W2895568417 cites W2768884966 @default.
- W2895568417 cites W2772828128 @default.
- W2895568417 cites W2777665097 @default.
- W2895568417 cites W2792230967 @default.
- W2895568417 cites W2952701400 @default.
- W2895568417 cites W4235710165 @default.
- W2895568417 doi "https://doi.org/10.1016/j.molliq.2018.10.008" @default.
- W2895568417 hasPublicationYear "2018" @default.
- W2895568417 type Work @default.
- W2895568417 sameAs 2895568417 @default.
- W2895568417 citedByCount "13" @default.
- W2895568417 countsByYear W28955684172019 @default.
- W2895568417 countsByYear W28955684172020 @default.
- W2895568417 countsByYear W28955684172021 @default.
- W2895568417 countsByYear W28955684172022 @default.
- W2895568417 countsByYear W28955684172023 @default.
- W2895568417 crossrefType "journal-article" @default.
- W2895568417 hasAuthorship W2895568417A5017395617 @default.
- W2895568417 hasAuthorship W2895568417A5030140325 @default.
- W2895568417 hasAuthorship W2895568417A5057984118 @default.
- W2895568417 hasAuthorship W2895568417A5068243422 @default.
- W2895568417 hasAuthorship W2895568417A5072472271 @default.
- W2895568417 hasAuthorship W2895568417A5076489975 @default.
- W2895568417 hasAuthorship W2895568417A5085140054 @default.
- W2895568417 hasAuthorship W2895568417A5087792094 @default.
- W2895568417 hasAuthorship W2895568417A5089778549 @default.
- W2895568417 hasConcept C11268172 @default.
- W2895568417 hasConcept C13965031 @default.
- W2895568417 hasConcept C15920480 @default.
- W2895568417 hasConcept C167092891 @default.
- W2895568417 hasConcept C178790620 @default.
- W2895568417 hasConcept C184651966 @default.
- W2895568417 hasConcept C185592680 @default.
- W2895568417 hasConcept C2776624427 @default.
- W2895568417 hasConcept C2780051471 @default.
- W2895568417 hasConcept C521977710 @default.
- W2895568417 hasConcept C55493867 @default.
- W2895568417 hasConcept C58226133 @default.
- W2895568417 hasConcept C64237528 @default.