FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895572986> ?p ?o ?g. }

• W2895572986 endingPage "5098" @default.
• W2895572986 startingPage "5083" @default.
• W2895572986 abstract "Life course changes in cardiovascular function in a non-human primate have been comprehensively characterized. Age-related declines in normalized left ventricular stroke volume and cardiac output were found with corresponding decreases in biventricular ejection fractions and filling rates. There were age-related decreases in male and female baboon normalized left ventricular myocardial mass index, which declined at similar rates. Systolic functional declines in right ventricular function were observed with age, similar to the left ventricle. Sex differences were found in the rates and directions of right ventricular volume changes along with decreased end-systolic right ventricular sphericity. The results validate the baboon as an appropriate model for translational studies of cardiovascular functional decline with ageing.Previous studies reported cardiac function declines with ageing. This study determined changes in biventricular cardiac function in a well-characterized baboon model. Cardiac magnetic resonance imaging measured key biventricular parameters in 47 baboons (22 female, age 4-23 years). ANCOVA assessed sex and age changes with P < 0.05 deemed significant. Stroke volume, cardiac output and other cardiac functional parameters were normalized to body surface area. There were similar, age-related rates of decrease in male (M) and female (F) normalized left ventricular (LV) myocardial mass index (M: -1.2 g m-2 year-1 , F: -0.9 g m-2 year-1 ). LV ejection fraction declined at -0.96% year-1 (r = -0.43, P = 0.002) and right ventricular (RV) ejection fraction decreased at -1.2% year-1 (r = -0.58, P < 0.001). Normalized LV stroke volume fell at -1.1 ml m-2 year-1 (r = -0.47, P = 0.001), normalized LV ejection rate at -3.8 ml s-1 m-2 year-1 (r = -0.43, P < 0.005) and normalized LV filling rate at -4.1 ml s-1 m-2 year-1 (r = -0.44, P < 0.005). Also, RV wall thickening fraction decreased with age (slope = -1% year-1 , P = 0.008). RV ejection rate decreased at -3.6 ml s-1 m-2 year-1 (P = 0.002) and the normalized average RV filling rate dropped at -3.7 ml s-1 m-2 year-1 (P < 0.0001). End-systolic RV sphericity index also dropped with age (r = -0.33, P = 0.02). Many observed changes parallel previously reported data in human and animal studies. These measured biventricular functional declines in hearts with ageing from the closest experimental primate species to man underscore the utility of the baboon model for investigating mechanisms related to heart ageing." @default.
• W2895572986 created "2018-10-12" @default.
• W2895572986 creator A5030651348 @default.
• W2895572986 creator A5036451016 @default.
• W2895572986 creator A5039492318 @default.
• W2895572986 creator A5044520373 @default.
• W2895572986 creator A5069145317 @default.
• W2895572986 date "2018-09-19" @default.
• W2895572986 modified "2023-10-09" @default.
• W2895572986 title "Ageing changes in biventricular cardiac function in male and female baboons (<i>Papio</i> spp.)" @default.
• W2895572986 cites W1825996051 @default.
• W2895572986 cites W1967640021 @default.
• W2895572986 cites W1969847513 @default.
• W2895572986 cites W1970032098 @default.
• W2895572986 cites W1976595890 @default.
• W2895572986 cites W1983972484 @default.
• W2895572986 cites W1985351983 @default.
• W2895572986 cites W1994514865 @default.
• W2895572986 cites W2024596192 @default.
• W2895572986 cites W2030322029 @default.
• W2895572986 cites W2031759793 @default.
• W2895572986 cites W2031882705 @default.
• W2895572986 cites W2035951405 @default.
• W2895572986 cites W2039465116 @default.
• W2895572986 cites W2042579836 @default.
• W2895572986 cites W2044804044 @default.
• W2895572986 cites W2046197884 @default.
• W2895572986 cites W2049364060 @default.
• W2895572986 cites W2058812724 @default.
• W2895572986 cites W2058918429 @default.
• W2895572986 cites W2073420794 @default.
• W2895572986 cites W2077686023 @default.
• W2895572986 cites W2079393398 @default.
• W2895572986 cites W2080632495 @default.
• W2895572986 cites W2083860193 @default.
• W2895572986 cites W2090876449 @default.
• W2895572986 cites W2105279719 @default.
• W2895572986 cites W2108790161 @default.
• W2895572986 cites W2111938953 @default.
• W2895572986 cites W2113273302 @default.
• W2895572986 cites W2113538204 @default.
• W2895572986 cites W2141569122 @default.
• W2895572986 cites W2142987571 @default.
• W2895572986 cites W2148426011 @default.
• W2895572986 cites W2155329925 @default.
• W2895572986 cites W2155343234 @default.
• W2895572986 cites W2155820750 @default.
• W2895572986 cites W2157815735 @default.
• W2895572986 cites W2157924841 @default.
• W2895572986 cites W2162217713 @default.
• W2895572986 cites W2164491113 @default.
• W2895572986 cites W2270188224 @default.
• W2895572986 cites W2366061453 @default.
• W2895572986 cites W2547284577 @default.
• W2895572986 cites W2576869859 @default.
• W2895572986 cites W2608575033 @default.
• W2895572986 cites W2747954651 @default.
• W2895572986 cites W2915048114 @default.
• W2895572986 cites W3014674295 @default.
• W2895572986 cites W4246305125 @default.
• W2895572986 cites W4293084779 @default.
• W2895572986 cites W593660800 @default.
• W2895572986 cites W92096595 @default.
• W2895572986 doi "https://doi.org/10.1113/jp276338" @default.
• W2895572986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6209749" @default.
• W2895572986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30144074" @default.
• W2895572986 hasPublicationYear "2018" @default.
• W2895572986 type Work @default.
• W2895572986 sameAs 2895572986 @default.
• W2895572986 citedByCount "13" @default.
• W2895572986 countsByYear W28955729862018 @default.
• W2895572986 countsByYear W28955729862019 @default.
• W2895572986 countsByYear W28955729862020 @default.
• W2895572986 countsByYear W28955729862021 @default.
• W2895572986 countsByYear W28955729862023 @default.
• W2895572986 crossrefType "journal-article" @default.
• W2895572986 hasAuthorship W2895572986A5030651348 @default.
• W2895572986 hasAuthorship W2895572986A5036451016 @default.
• W2895572986 hasAuthorship W2895572986A5039492318 @default.
• W2895572986 hasAuthorship W2895572986A5044520373 @default.
• W2895572986 hasAuthorship W2895572986A5069145317 @default.
• W2895572986 hasBestOaLocation W28955729861 @default.
• W2895572986 hasConcept C111566952 @default.
• W2895572986 hasConcept C126322002 @default.
• W2895572986 hasConcept C139940330 @default.
• W2895572986 hasConcept C164705383 @default.
• W2895572986 hasConcept C178853913 @default.
• W2895572986 hasConcept C2778198053 @default.
• W2895572986 hasConcept C2778921608 @default.
• W2895572986 hasConcept C2779594886 @default.
• W2895572986 hasConcept C31861589 @default.
• W2895572986 hasConcept C500499127 @default.
• W2895572986 hasConcept C71924100 @default.
• W2895572986 hasConcept C78085059 @default.
• W2895572986 hasConcept C80461066 @default.
• W2895572986 hasConceptScore W2895572986C111566952 @default.
• W2895572986 hasConceptScore W2895572986C126322002 @default.
• W2895572986 hasConceptScore W2895572986C139940330 @default.

• next