Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895574251> ?p ?o ?g. }
- W2895574251 endingPage "13" @default.
- W2895574251 startingPage "1" @default.
- W2895574251 abstract "TNIP1 protein is increasingly being recognized as a key repressor of inflammatory signaling and a potential factor in multiple autoimmune diseases. In addition to earlier foundational reports of TNIP1 SNPs in human autoimmune diseases and TNIP1 protein-protein interaction with receptor regulating proteins, more recent studies have identified new potential interaction partners and signaling pathways likely modulated by TNIP1. Subdomains within the TNIP1 protein as well as how they interact with ubiquitin have not only been mapped but inflammatory cell- and tissue-specific consequences subsequent to their defective function are being recognized and related to human disease states such as lupus, scleroderma, and psoriasis. In this review, we emphasize receptor signaling complexes and regulation of cytoplasmic signaling steps downstream of TLR given their association with some of the same autoimmune diseases where TNIP1 has been implicated. TNIP1 dysfunction or deficiency may predispose healthy cells to the inflammatory response to otherwise innocuous TLR ligand exposure. The recognition of the anti-inflammatory roles of TNIP1 and improved integrated understanding of its physical and functional association with other signaling pathway proteins may position TNIP1 as a candidate target for the design and/or testing of next-generation anti-inflammatory therapeutics." @default.
- W2895574251 created "2018-10-12" @default.
- W2895574251 creator A5006767766 @default.
- W2895574251 creator A5069952158 @default.
- W2895574251 date "2018-10-03" @default.
- W2895574251 modified "2023-10-03" @default.
- W2895574251 title "TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling" @default.
- W2895574251 cites W11653250 @default.
- W2895574251 cites W1496240740 @default.
- W2895574251 cites W1505701939 @default.
- W2895574251 cites W1538131965 @default.
- W2895574251 cites W1588555436 @default.
- W2895574251 cites W1626010195 @default.
- W2895574251 cites W1655484798 @default.
- W2895574251 cites W1724470194 @default.
- W2895574251 cites W1793115003 @default.
- W2895574251 cites W1795583523 @default.
- W2895574251 cites W190882897 @default.
- W2895574251 cites W1926638744 @default.
- W2895574251 cites W1939997832 @default.
- W2895574251 cites W1955733588 @default.
- W2895574251 cites W1964739310 @default.
- W2895574251 cites W1964962218 @default.
- W2895574251 cites W1965544877 @default.
- W2895574251 cites W1971436438 @default.
- W2895574251 cites W1971708477 @default.
- W2895574251 cites W1972985967 @default.
- W2895574251 cites W1973431560 @default.
- W2895574251 cites W1977455495 @default.
- W2895574251 cites W1978432948 @default.
- W2895574251 cites W1980009864 @default.
- W2895574251 cites W1986161286 @default.
- W2895574251 cites W1986241110 @default.
- W2895574251 cites W1987784314 @default.
- W2895574251 cites W1988376074 @default.
- W2895574251 cites W1988960331 @default.
- W2895574251 cites W1989223663 @default.
- W2895574251 cites W1991750160 @default.
- W2895574251 cites W1993136355 @default.
- W2895574251 cites W1993211211 @default.
- W2895574251 cites W1994799948 @default.
- W2895574251 cites W1995111406 @default.
- W2895574251 cites W1995744610 @default.
- W2895574251 cites W2000792279 @default.
- W2895574251 cites W2001747259 @default.
- W2895574251 cites W2003742101 @default.
- W2895574251 cites W2004534466 @default.
- W2895574251 cites W2006249161 @default.
- W2895574251 cites W2008646773 @default.
- W2895574251 cites W2011236111 @default.
- W2895574251 cites W2013787067 @default.
- W2895574251 cites W2014762730 @default.
- W2895574251 cites W2015828571 @default.
- W2895574251 cites W2016932623 @default.
- W2895574251 cites W2019140431 @default.
- W2895574251 cites W2022509419 @default.
- W2895574251 cites W2024866056 @default.
- W2895574251 cites W2026512029 @default.
- W2895574251 cites W2030863339 @default.
- W2895574251 cites W2031580483 @default.
- W2895574251 cites W2032215329 @default.
- W2895574251 cites W2033562377 @default.
- W2895574251 cites W2035909252 @default.
- W2895574251 cites W20377036 @default.
- W2895574251 cites W2043801813 @default.
- W2895574251 cites W2043948229 @default.
- W2895574251 cites W2045022575 @default.
- W2895574251 cites W2045113343 @default.
- W2895574251 cites W2045384882 @default.
- W2895574251 cites W2048531476 @default.
- W2895574251 cites W2049572499 @default.
- W2895574251 cites W2049781542 @default.
- W2895574251 cites W2051026238 @default.
- W2895574251 cites W2051177901 @default.
- W2895574251 cites W2051569082 @default.
- W2895574251 cites W2053429123 @default.
- W2895574251 cites W2056119728 @default.
- W2895574251 cites W2063211255 @default.
- W2895574251 cites W2064229941 @default.
- W2895574251 cites W2069034996 @default.
- W2895574251 cites W2073453659 @default.
- W2895574251 cites W2075083870 @default.
- W2895574251 cites W2075181458 @default.
- W2895574251 cites W2078744808 @default.
- W2895574251 cites W2079267030 @default.
- W2895574251 cites W2082268112 @default.
- W2895574251 cites W2088051577 @default.
- W2895574251 cites W2088529501 @default.
- W2895574251 cites W2091258552 @default.
- W2895574251 cites W2099978636 @default.
- W2895574251 cites W2101981157 @default.
- W2895574251 cites W2102889851 @default.
- W2895574251 cites W2104904748 @default.
- W2895574251 cites W2104914251 @default.
- W2895574251 cites W2110888991 @default.
- W2895574251 cites W2111312476 @default.
- W2895574251 cites W2115027287 @default.
- W2895574251 cites W2117197896 @default.