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- W2895578971 abstract "Monocrotaline is well established to cause pulmonary arterial hypertension and right heart failure. To characterize the development of monocrotaline-induced heart failure in Wistar rats, Millar telemetry devices were used to follow arterial pressure and heart rate for six weeks following a single subcutaneous injection of either monocrotaline (60 mg/kg) or saline. Four weeks after monocrotaline injection, mean arterial, systolic, diastolic and pulse pressures all began to decrease progressively. This decrease in pressure was accompanied by a progressive increase in heart rate until 5 weeks post-injection when heart rate began to fall again. Ventricular function was assessed 6 weeks post-injection by placement of pressure volume catheters in both the left and right ventricles. Reduced ejection fraction and dP/dt max indicated reduced contractile function of both the left and right ventricles in the monocrotaline-treated rats compared to the saline-treated controls. Support or Funding Information Supported ..." @default.
- W2895578971 created "2018-10-12" @default.
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- W2895578971 date "2016-04-01" @default.
- W2895578971 modified "2023-09-23" @default.
- W2895578971 title "The Effect of Monocrotaline-Induced Heart Failure on Left- and Right-Ventricular Function" @default.
- W2895578971 doi "https://doi.org/10.1096/fasebj.30.1_supplement.958.6" @default.
- W2895578971 hasPublicationYear "2016" @default.
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