FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2895580591> ?p ?o ?g. }

• W2895580591 endingPage "924A" @default.
• W2895580591 startingPage "924A" @default.
• W2895580591 abstract "SESSION TITLE: Systemic Disease and the Lung 1 SESSION TYPE: Original Investigations PRESENTED ON: 10/07/2018 01:00 PM - 02:00 PM PURPOSE: Extramedullary hematopoiesis (EMH) is a complication of a variety of myeloproliferative neoplasms. The most common sites of EMH are the spleen and liver; however the involvement of other sites has been reported (1). The lungs and pleura are a rare site of EMH and have been reported to present with a variety of signs and symptoms (2). Here we present a series of 47 patients with confirmed EMH of the lung, the largest series to date. METHODS: We reviewed an internal database that captured 47 patients with EMH of the lung confirmed on nuclear medicine technetium scans or by biopsy from 1997-2012 at the Mayo Clinic in Rochester, Minnesota. RESULTS: Clinical manifestations were largely non-specific (fatigue 93%, dyspnea 85%, cough 30%, weight loss 30%). Imaging abnormalities were similarly non-specific but included pleural effusions (57%) and ground-glass opacities (43%) on chest CT imaging. Twenty-seven patients underwent echocardiographic evaluation of right ventricular systolic pressure(RVSP). Twenty one (78%) had elevated RVSP at time of diagnosis (>36 mm Hg) with an overall mean RVSP of 54.48 mm Hg. Sixteen of 47 (34%) of patients had had prior splenectomy. Twenty nine patients were subsequently treated with low dose (100 centigray) whole lung irradiation. Twenty one (72%) had subjective symptomatic improvement as judged by their hematologist in documentation. Of these 29 patients who received radiation, 13 underwent post-radiation echocardiography and the mean RVSP increased to 59.8 mm Hg, although this may not be clinically significant. In terms of prognosis, 42 of our 47 patients had known date/time of death, and median time from diagnosis to death was 7.5 months. This was increased to 17 months in those who received radiation and reduced to 4.5 months for those who did not. CONCLUSIONS: We conclude that EMH of the lung is associated with a poor prognosis and that radiation therapy may be associated with improved symptoms and longer survival. CLINICAL IMPLICATIONS: Our findings suggest that clinicians need to maintain a high degree of suspicion for EMH of the lung in patients with myeloproliferative neoplasms, as there are no specific signs or symptoms for this entity. Whole lung irradiation seems to be an effective symptomatic treatment for EMH of the lung for many patients, and receiving irradiation may be associated with improved overall survival. Finally, EMH of the lung is a poor prognostic factor and finding it may prompt clinicians to discuss end of life care with their patients. DISCLOSURES: No relevant relationships by Tariq Azam, source=Web Response No relevant relationships by Megan Dulohery Scrodin, source=Web Response" @default.
• W2895580591 created "2018-10-12" @default.
• W2895580591 creator A5013516245 @default.
• W2895580591 creator A5071111074 @default.
• W2895580591 date "2018-10-01" @default.
• W2895580591 modified "2023-09-27" @default.
• W2895580591 title "EXTRAMEDULLARY HEMATOPOIESIS OF THE LUNG: A CASE SERIES" @default.
• W2895580591 doi "https://doi.org/10.1016/j.chest.2018.08.831" @default.
• W2895580591 hasPublicationYear "2018" @default.
• W2895580591 type Work @default.
• W2895580591 sameAs 2895580591 @default.
• W2895580591 citedByCount "0" @default.
• W2895580591 crossrefType "journal-article" @default.
• W2895580591 hasAuthorship W2895580591A5013516245 @default.
• W2895580591 hasAuthorship W2895580591A5071111074 @default.
• W2895580591 hasConcept C109159458 @default.
• W2895580591 hasConcept C126322002 @default.
• W2895580591 hasConcept C126838900 @default.
• W2895580591 hasConcept C197934379 @default.
• W2895580591 hasConcept C2777482430 @default.
• W2895580591 hasConcept C2777714996 @default.
• W2895580591 hasConcept C2778080410 @default.
• W2895580591 hasConcept C2779563453 @default.
• W2895580591 hasConcept C28328180 @default.
• W2895580591 hasConcept C54355233 @default.
• W2895580591 hasConcept C71924100 @default.
• W2895580591 hasConcept C86803240 @default.
• W2895580591 hasConceptScore W2895580591C109159458 @default.
• W2895580591 hasConceptScore W2895580591C126322002 @default.
• W2895580591 hasConceptScore W2895580591C126838900 @default.
• W2895580591 hasConceptScore W2895580591C197934379 @default.
• W2895580591 hasConceptScore W2895580591C2777482430 @default.
• W2895580591 hasConceptScore W2895580591C2777714996 @default.
• W2895580591 hasConceptScore W2895580591C2778080410 @default.
• W2895580591 hasConceptScore W2895580591C2779563453 @default.
• W2895580591 hasConceptScore W2895580591C28328180 @default.
• W2895580591 hasConceptScore W2895580591C54355233 @default.
• W2895580591 hasConceptScore W2895580591C71924100 @default.
• W2895580591 hasConceptScore W2895580591C86803240 @default.
• W2895580591 hasIssue "4" @default.
• W2895580591 hasLocation W28955805911 @default.
• W2895580591 hasOpenAccess W2895580591 @default.
• W2895580591 hasPrimaryLocation W28955805911 @default.
• W2895580591 hasRelatedWork W2002447263 @default.
• W2895580591 hasRelatedWork W2049214470 @default.
• W2895580591 hasRelatedWork W2086501868 @default.
• W2895580591 hasRelatedWork W2347534785 @default.
• W2895580591 hasRelatedWork W2364486725 @default.
• W2895580591 hasRelatedWork W2394336024 @default.
• W2895580591 hasRelatedWork W2765985895 @default.
• W2895580591 hasRelatedWork W2902148150 @default.
• W2895580591 hasRelatedWork W3005652238 @default.
• W2895580591 hasRelatedWork W3111892599 @default.
• W2895580591 hasVolume "154" @default.
• W2895580591 isParatext "false" @default.
• W2895580591 isRetracted "false" @default.
• W2895580591 magId "2895580591" @default.
• W2895580591 workType "article" @default.